Registration Dossier
Registration Dossier
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EC number: 701-325-7 | CAS number: -
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Efficacy of Antiperspirants on Feet
- Author:
- Darrigrand, A., Reynolds, K., Jackson, R.
- Year:
- 1 992
- Bibliographic source:
- Military Medicine, 157, 5:256, 1992
Materials and methods
Test material
- Reference substance name:
- Aluminum chloride, basic
- EC Number:
- 215-477-2
- EC Name:
- Aluminum chloride, basic
- Cas Number:
- 1327-41-9
- Molecular formula:
- General formula: Al(OH)x(Cl)(3-x), with x ranging from 0.1 to 2.3
- IUPAC Name:
- Aluminum chloride, basic
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- This study indicates that the use of antiperspirants on the foot will: (1) reduce foot-sweat accumulation and, (2) increase the incidence of irritant
dermatitis. The reduced foot-sweat accumulation may also help to reduce foot blistering during exercise in warm environments. In cold
environments, the reduced foot-sweat accumulation should be a benefit in reducing the incidence of trench foot and frostbite injuries. Future
research should address changing the antiperspirant formula to reduce the incidence of irritant dermatitis and to clarify whether or not
antiperspirants can reduce the occunence of foot blisters. - Executive summary:
Nineteen male soldiers participated in a study of the effectiveness of two antiperspirants (aluminum chlorohydrate and aluminum zirconium tetrachlorohydrex glycine) in reducing foot-sweat accumulation and injuries. Each subject was tested before and after antiperspirant application, with a 1-hour treadmill march at 5.6 km/hour in a warm environment. Both antiperspirants decreased (p<0.05) foot-sweat accumulation over 50%. There was also a tendency, although not statistically significant, for subjects to incur fewer blisters with antiperspirant use. However, the antiperspirants also increased (p<0.05) the incidence of irritant dermatitis. Nevertheless, these data suggest that the application of antiperspirants to the feet has merit in reducing serious foot injuries (blisters, trench foot] exacerbated by wet feet.
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