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EC number: 845-727-1 | CAS number: 1919868-77-1
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 Sep - 06 Okt 2021
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)
- Version / remarks:
- 1996
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Version / remarks:
- 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- July 1995
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
Test material
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- -2.75
- Temp.:
- 20 °C
- pH:
- >= 4.18 - <= 4.2
- Details on results:
- A partition coefficient was calculated from data of each run. Alto-gether six values were obtained for each experiment. The six log Pow values were determined within a range of +/- 0.3 units.
According to this study the logarithmic partition coefficient (n octanol/water) of the test item was determined to be - 2.75 using the shake flask method at 20 °C ± 0.7°C.
Any other information on results incl. tables
| Sample Description | absolute amount test item measured | absolute amount test item nominal | cow/cw | log Po/w |
| [mg] | [mg] | |||
| 1 | 63 | 65 | 0.0018 | -2.75 |
| 2 | 63 | 65 | 0.0017 | -2.77 |
| 3 | 41 | 42 | 0.0017 | -2.77 |
| 4 | 41 | 42 | 0.0017 | -2.76 |
| 5 | 82 | 84 | 0.0018 | -2.74 |
| 6 | 81 | 84 | 0.0018 | -2.75 |
Applicant's summary and conclusion
- Conclusions:
- According to this study the logarithmic partition coefficient (n octanol/water) of the test item was determined to be - 2.75 using the shake flask method at 20 °C ± 0.7°C.
- Executive summary:
Test Method: The partition coefficient of the test item was determined using the shake flask method.
Results:
The partition coefficient was calculated based on the results of the analytical determination following a shake flask test according to OECD Guideline 107. The test item content was determined by via U-HPLC. The log Pow was calculated for each run. The difference between the three different test variants was less than the given ± 0.3 log units. Therefore, the study can be considered to be valid.
According to this study the logarithmic partition coefficient (n‑octanol/water) of the test item was determined to be -2.75 using the shake flask method at 20 °C ± 0.7 °C.
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