Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 801-773-4 | CAS number: 1550-44-3
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 08 July 2014 to 22 October 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Version / remarks:
- 1981
- GLP compliance:
- yes (incl. QA statement)
- Dissociating properties:
- no
- Remarks:
- 2,2-Difluoroethyl acetate was not found to dissociate in the environmentally significant pH range (pH 2 to 12).
- Conclusions:
- 2,2-Difluoroethyl acetate was demonstrated not to dissociate in the environmentally significant pH range (pH 2 to 12).
- Executive summary:
The pKa of 2,2-Difluoroethyl acetate was investigated in a GLP-compliant study according to the OECD test guideline 112. 2,2-Difluoroethyl acetate was not found to dissociate in the environmentally significant pH range (pH 2 to 12).
Reference
There was no significant difference in the shape of the sample titration curves from the acidic and basic titrations, indicating no dissociation of the test substance within the pH range investigated.
Description of key information
2,2-Difluoroethyl acetate does not dissociate in the environmentally significant pH range (pH 2 to 12).
Key value for chemical safety assessment
Additional information
An experimental study performed under GLP compliance and in accordance with OECD test guideline 112 was flagged as a key study and assigned a Klimisch score of 1. It reports that 2,2-Difluoroethyl acetate does not dissociate in the environmentally significant pH range (pH 2 to 12). The test item has no pKa.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
