Registration Dossier
Registration Dossier
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EC number: 216-629-0 | CAS number: 1630-78-0
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Type of information:
- (Q)SAR
- Remarks:
- TOXTREE
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source
- Justification for type of information:
- 1. SOFTWARE
Toxtree (stimation of Toxic Hazard - Decision Tree Approach)
2. MODEL (incl. version number)
v3.1.0-1851
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
F\C=C\F
4. APPLICABILITY DOMAIN
Toxtree is based on classification trees and does not provide such information and thus no reliability is assigned. All original model results are presented in the software printout section.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
- Principles of method if other than guideline:
- - Principle of test: QSAR for skin sensitisation
- Short description of test conditions: n/a
- Parameters analysed / observed: QSAR for skin sensitisation (TOXTREE) - GLP compliance:
- no
Test material
- Reference substance name:
- (E)-1,2-difluoroethylene
- EC Number:
- 216-629-0
- EC Name:
- (E)-1,2-difluoroethylene
- Cas Number:
- 1630-78-0
- Molecular formula:
- C2H2F2
- IUPAC Name:
- (E)-1,2-difluoroethene
- Test material form:
- gas
Constituent 1
Results and discussion
In vitro / in chemico
Results
- Run / experiment:
- other: QSAR: TOXTREE
- Remarks on result:
- positive indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- It was identified in Toxtree in the Skin sensitisation reactivity domains an alert for SN2 nucleophilic aliphatic substitution was fired, suggesting a potential for sensitisation.
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