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EC number: 235-384-0 | CAS number: 12207-63-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 17.8 µg/L
- Assessment factor:
- 3
- Extrapolation method:
- sensitivity distribution
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 2.5 µg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 450 µg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 563 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 79 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 7.2 mg/kg soil dw
- Assessment factor:
- 3
- Extrapolation method:
- sensitivity distribution
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- PNEC oral
- PNEC value:
- 0.167 mg/kg food
- Assessment factor:
- 30
Additional information
Ammonium trivanadium octaoxide is soluble in water (180-260 mg/L at pH∼4, 20°C) and based on information available for other soluble vanadium substances can be assumed to be also soluble in environmental media. In a standard transformation/dissolution test according to OECD Series No 29 with a loading of 1 mg/L, a nearly complete dissolution of soluble inorganic pentavalent vanadium substances ( (91-98% for V2O5 and NaVO3) was observed after 24h at pH 8 and pH 6. Further, the solubility of ammonium trivanadium octaoxide is expected to determine its behaviour and fate in the environment, and subsequently its bioavailability and potential for bioaccumulation and ecotoxicity. Pentavalent vanadium substances (V2O5, NaVO3) at pH 6 and 8, similar to other inorganic vanadium substances, release pentavalent vanadium ions (83-89% (V(V) after 24 hours) that are retained in pentavalent form (84-95% V(V) after 28 days). Therefore, a read-across approach is applied based on all information available for different inorganic vanadium substances and the fate of released vanadium ions can be expected to be similar to the common fate of vanadium ions in the environment. Further information on the applied read-across approach is summarized below.
Read-across approach
In the assessment of the environmental fate and behaviour of inorganic vanadium substances, a read-across approach is applied based on all information available for different inorganic vanadium substances. This grouping of vanadium substances for estimating their environmental fate and toxicity is based on the assumption that properties are likely to be similar or follow a similar pattern as a result of the presence of the common vanadium ion. After emission of metal (vanadium) substances into the environment, it is the potentially bioavailable metal ion (vanadium ion) that is liberated (to a greater or lesser extent) upon contact with environmental solutions, including sediment and soil porewater, and that is the moiety of ecotoxicological concern.This assumption can be considered valid when:
i) differences in solubility among V compounds do not affect the results for ecotoxicity,
ii) ecotoxicity is only affected by the vanadium-ion and not by the counter ions, and
iii) there are no important differences in speciation of vanadium in the environment after emissions of the various V compounds.
Reliable ecotoxicity date of soluble vanadium substances were selected, and respective effect concentrations are based on measured (dissolved) vanadium concentrations. In assessing the ecotoxicity of metals in the various environmental compartments (aquatic, terrestrial and sediment), it is assumed that toxicity is not controlled by the total concentration of a metal, but by the bioavailable fraction. For metals, this bioavailable fraction is generally accepted to be the free metal-ion or oxy-anion in solution. Conservatively, it can also be assumed that the total dissolved vanadium fraction is bioavailable.
The reliable ecotoxicity data are based on pentavalent V substances (NaVO3, NH4VO3, Na3VO4, V2O5, Ca3(VO4)2, (NH4)V3O8), except for one avian toxicity study with VOSO4. All counter-ions (Na+, (NH4)+, Ca2+, and (SO4)2-) are abundantly present in natural environments and/or are essential and are therefore not expected to cause any toxic effects at the concentrations tested.
Vanadium can exist in a multitude of different oxidation states from -2 to +5. However, being a first-row transition element, vanadium has the tendency to exist in high oxidation states (+3, +4 and +5), and vanadium ions will form oxy complexes in aqueous solutions (Cotton and Wilkinson, 1988; Crans et al., 1998). The aqueous chemistry of the metal is complex and involves a wide range of oxygenated species for which stabilities depend mainly on the acidity and oxygen level of receiving waters. Under conditions commonly found in oxic fresh waters (i.e., pH between 5 and 9; redox potential [Eh] between 0.5 and 1 V), the pentavalent forms will be the dominant species in solution (Brookins, 1988; Crans et al., 1998; Takeno, 2005, Larsson et al., 2015a). Tetravalent vanadium also may exist under some specific conditions (e.g. pH< 5). Soil organic matter, which strongly adsorbs to tetra- and pentavalent vanadium species, may potentially reduce V(V) to V(IV), therefore lowering its overall bioaccessibility (Reijonen et al., 2016). It is therefore assumed that upon dissolution of inorganic vanadium substances, the environmental conditions control the (redox) speciation of vanadium in water, soil and sediment, independently of the identity of the V substance.
This is confirmed by redox speciation analysis of dissolved vanadium during transformation/dissolution tests for vanadium metal and vanadium substances with different valence states (including V, V2O3, VOSO4, NaVO3, V2O5) according to OECD Series No 29 (2009). The tests were conducted at a loading of 1 mg/L over 28 days in standard OECD test media at pH 6 and pH 8 under a set of standard laboratory conditions representative of those in standard OECD aquatic ecotoxicity tests. The redox speciation of dissolved vanadium was measured by separating V(IV) and V(V) species by HPLC and analysis by ICP- MS. Regardless of the original valency of the vanadium substance, dissolved V at pH 6 and pH 8 is predominantly present in the pentavalent V form (75-97% of all V), with some traces of V(IV). Recovery of total dissolved V by measured V(V) and V(IV) was on average 96% and did not differ significantly among the substances tested.
Similar observations were made in laboratory experiments at pH 6: In a study performed by Larsson et al. (2015a) using natural soils spiked with vanadium (IV) or vanadium (V), pentavalent vanadium predominated in soil extracts after a 10-d equilibration period. Therefore, vanadium speciation in soil solution was independent of the valence state of the added salt. Accordingly, Reijonen et al. (2016) demonstrated that vanadium speciation (and bioavailability) is mainly regulated by soil organic matter (SOM) and soil pH under oxic conditions, whereas the original valence state of the added vanadium substance is negligible for controlling distribution and water solubility. In line with these findings, long-term investigations (26 years) on fate and transformation of vanadium species performed by Larsson et al. (2015b) on vanadium-containing converter lime applied to pine forest soil suggest further that the long-term speciation is governed by soil properties (pH, SOM, metal hydroxides) and less dependent on the initial valence state.
Based on this information, it was concluded that the read-across conditions stated above are met. Therefore, all toxicity data based on soluble V substances (i.e. maximal bioavailability) are used in a read-across approach and results are expressed based on elemental vanadium concentrations.For further information on the applied read-across approach, please refer to the RAAF document "Read-across approach for environmental toxicity of the vanadium category, 2020" attached in IUCLID Section 13.
Conclusion on classification
Acute and chronic reference values for environmental classification are based on standard tests in accordance with Regulation (EC) No 440/2008 on “test methods pursuant to Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH)”.
Acute and long-term toxicity data for vanadium are available for the three trophic levels. The lowest L(E)C50 for fish, crustacean or algae growth rate is a 96-h LC50 of 0.693 mg V/L (based on dissolved V concentration), observed for the effect of V2O5 flakes in a GLP-conform standard test with Leuciscus idus (Mitterer, 1999). This value is selected as the acute ecotoxicity reference value for classification.
The lowest chronic NOEC or EC10 for freshwater fish, invertebrates or algae from a standard test is the 28-d EC10 of 0.203 mg V/L for the effect of V2O5 on growth (weight) of Pimephales promelas (Kimball, 1978), and this value is selected as chronic reference value for classification. Available chronic NOEC/EC10 values derived in non-standard tests with non-standard species were not applied for classification conclusions as follows:
- The 21-d EC10 of 0.05 mg V/L (based on dissolved V concentration) for the effect of NaVO3 in a 21-day reproduction test with neonate daphnids (Daphnia dentifera) (Schiffer and Liber, 2017): Daphnia dentifera is not a standard daphnia species and tested specimen were field-collected in Canada. The species is considered of lower relevance in European freshwaters compared to standard organisms, and results were therefore not selected for classification.
- The 30-d EC10 of 0.076 mg V/L (based on dissolved V concentration) for the effect of V2O5 in a 30-day growth test with second generation flagfish larvae (Jordanella floridae) originating from exposed fish (Holdway and Sprague, 1979): This non-standard fish species was exposed in a non-standard test.
- The chronic 14-d EC10 of 0.081 mg V/L for the effect of NaVO3 on reproduction of Aeolosoma sp. (Stubblefield, 2017): was derived with a non-standard species in a non-standard test.
The acute and long-term ecotoxicity reference values of 0.693 and 0.203 mg V/L, respectively, are based on dissolved elemental V concentrations and are applied for the classification of inorganic vanadium substances. Since vanadium is an inorganic element, biodegradation is not relevant.
For the classification of ammonium trivanadium octaoxide, the acute and long-term ecotoxicity reference values (in mg V/L) are converted based on the vanadium content of ammonium trivanadium octaoxide (51% V), resulting in 1.36 and 0.40 mg (NH4)V3O8/L, respectively. Based on these ecotoxicity reference values and classification criteria of Regulation (EC) No 1272/2008, Table 4.1.0 (a), ammonium trivanadium octaoxide does not meet classification criteria of Acute (short-term) aquatic hazard (acute reference value > 1 mg/L). In accordance with Table 4.1.0 (b(i)), ammonium trivanadium octaoxide as not-rapidly degradable substance meets criteria of “Aquatic Category Chronic 2” (chronic reference value >0.1 and ≤1 mg/L). Thus, ammonium trivanadium octaoxide is classified as Long-term Aquatic Hazard Category 2 (H 411).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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