Registration Dossier
Registration Dossier
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EC number: 404-310-0 | CAS number: 10591-85-2 PERKACIT TBZTD; PERKACIT TBZTD PDR; PERKACIT TBZTD PDR-D; TBZD
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Directive EEC 84/449, Annex V, B.1
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Tetrakis(phenylmethyl)thioperoxydi(carbothioamide)
- EC Number:
- 404-310-0
- EC Name:
- Tetrakis(phenylmethyl)thioperoxydi(carbothioamide)
- Cas Number:
- 10591-85-2
- Molecular formula:
- C30-H28-N2-S4
- IUPAC Name:
- N,N-dibenzyl[(dibenzylcarbamothioyl)disulfanyl]carbothioamide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- Wistar CrL: (Wi) BR (outbred, SPF quality)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- methylcellulose
- Details on oral exposure:
- Substance delivered in 1% aqueousmethyl cellulose.
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 5 000 mg/kg bw
- Remarks on result:
- other:
- Remarks:
- no mortality
- Mortality:
- No mortality occurred at 5000 mg/kg/day in males and females
- Clinical signs:
- other: No signs of systemic toxicity were observed during the observation period.
- Gross pathology:
- No effects were found after sacrifice on day 15.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions used in this study, it is concluded that the oral LD50 value of TBzTD in the rat exceeds 5000 mg/kg bodyweight for both males and females
- Executive summary:
One group of Wistar rats, comprising 5 males and 5 females, received a total oral dose of Tetrabenzylthiuram disulfide at 5000 mg/kg bw (2500 mg/kg twice within 24 hours).
No mortality occurred and no signs of toxicity were observed during the 14 day observation period.
Post-mortem examination of all animals at the end of the study did not reveal any changes that were considered to have arisen as a result of treatment.
Since no mortality occurred, the oral LD50 value for both males and females was noted as exceeding 5000 mg/kg bodyweight.
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