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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1990
Report date:
1990

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Version / remarks:
1981
Deviations:
no
GLP compliance:
yes
Test type:
acute toxic class method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Tetrakis(phenylmethyl)thioperoxydi(carbothioamide)
EC Number:
404-310-0
EC Name:
Tetrakis(phenylmethyl)thioperoxydi(carbothioamide)
Cas Number:
10591-85-2
Molecular formula:
C30-H28-N2-S4
IUPAC Name:
N,N-dibenzyl[(dibenzylcarbamothioyl)disulfanyl]carbothioamide
Details on test material:
Physical form of substance: S
Mass median aerodynamic diameter (for liq.+solid aerosol):
MMAD has not been calculated. 47.7 % of particles =< 3 µm.
Cummulative particle size:
Percent Effective cutoff diameter
4.0 < 0.325
4.2 0.325
4.7 0.715
6.3 1.06
11.0 1.60
26.8 2.13
27.7 3.0
100 4.6

Test animals

Species:
rat
Strain:
Wistar
Remarks:
Wistar rat, KFM-HAN, outbred, SPF quality
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: mist
Type of inhalation exposure:
nose only
Vehicle:
air
Remark on MMAD/GSD:
MMAD has not been calculated. 47.7% of particles =< 3 um
Duration of exposure:
4 h
Concentrations:
0.78 and 5.03 mg/L
No. of animals per sex per dose:
5
Control animals:
no
Statistics:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
5.03 mg/L air
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other:
Remarks:
no mortality
Mortality:
No mortality occurred in males and females
Clinical signs:
other: At the concentration of 5.03 mg/L, some excitement was noted during exposure. Slight breathing difficulty (males and females) and piloerection (males only) were noted just after exposure.
Body weight:
no data
Gross pathology:
No abnormal observations were made in an of any groups.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The acute 4-hour inhalation toxicity of TETRABENZYLTHIURAM DISULFIDE in rats of both sexes observed over a period of 15 days was estimated to be higher than 5.03 mg/L air
Executive summary:

One group of Wistar rats, comprising 5 males and 5 females, were exposed to 0.78 or 5.03 mg/L for 4 hours to dust of TBzTD.

No mortality occurred during the 14 day observation period. At the concentration of 5.03 mg/L, some excitement was noted during exposure. Slight breathing difficulty (males and females) and piloerection (males only) were noted just after exposure. No clinical signs were observed in animal treated with 0.78 mg/L.

Post-mortem examination of all animals at the end of the study did not reveal any changes that were considered to have arisen as a result of treatment.

Since no mortality occurred, the LC50 value for both males and females was noted as exceeding 5.03 mg/L.