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Diss Factsheets
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EC number: 932-179-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 Jun - 27 Aug 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Food and Consumer Product Safety Authority, Prinses Beatrixlaan 2, 2595 AL Den Haag, Postbus 19506, 2500 CM Den Haag, The Netherlands, 30 March 2009
- Type of method:
- flask method
- Water solubility:
- 38.7 g/L
- Temp.:
- 20 °C
- pH:
- 3.5 - 3.6
- Remarks on result:
- other: At a loading rate of 100 g/L the water solubility of the test substance was 38.7 g/L. It corresponds with a water solubility percentage compared to the loading rate of 39%.
- Water solubility:
- 268 g/L
- Temp.:
- 20 °C
- pH:
- 3.5
- Remarks on result:
- other: At the maximum loading rate of 1:1 w/v (maximum loading rate according to the guidelines) the water solubility of the test substance was 268 g/L. It corresponds with a water solubility of 27% compared to the loading rate.
- Details on results:
- Vinasses is a UVCB product. The flask method at two loading rates was chosen for the determination of the water solubility of the test substance.
The water solubility of the test substance at 20 °C increased with the loading rate of the samples. - Conclusions:
- Interpretation of results:
The test substance contains a large fraction of components with a relatively high water solubility . However, the test substance was not completely soluble in water since in all samples undissolved test substance particles were observed.
Vinasses is a UVCB product. The flask method at two loading rates was chosen for the determination of the water solubility of the test substance.
The water solubility of the test substance at 20 °C increased with the loading rate of the samples. At a loading rate of 100 g/L the water solubility of the test substance was 38.7 g/L. It corresponds with a water solubility percentage compared to the loading rate of 39%. The pH of the aqueous samples was 3.5 – 3.6.
At the maximum loading rate of 1:1 w/v (maximum loading rate according to the guidelines) the water solubility of the test substance was 268 g/L. It corresponds with a water solubility of 27% compared to the loading rate. The pH of the samples was 3.5.
Based on the results obtained it was concluded that the test substance contains a large fraction of components with a relatively high water solubility (i.e. 268 g/L at a 1:1 w/v loading rate). The test substance was not completely soluble in water since in all samples undissolved test substance particles were observed.
Reference
Preliminary test
The content of the test substance in the water sample at the loading rate of 100 g/L and 1000 g/L (1:1 w/v ratio) was 41.4 g/L and 283 g/L, respectively.
The preliminary test demonstrated that the test substance contains a large fraction of components with a relatively high water solubility. According to this, the maximum loading rate of 1000 g/L (1:1 w/v) and a 10-times lower loading rate of 100 g/L were applied in the main study.
Main study
The results for the samples at the loading rates of 100 g/L and 1:1 w/v taken at 24, 48 and 72 hours are given in the tables below.
The maximum difference (MD) of the 24-hour sample at the loading rate of 100 g/L was somewhat lower than the 48- and 72- hour measurements (maximum difference > 15%). According to the guidelines, the water solubility of the test substance was given as the mean value of the 48- and 72-hour measurements.
At a ratio of 1:1 w/v, the MD of the concentrations determined in the 24, 48 and 72 hour test samples was < 15%. According to the guidelines, the water solubility of the test substance is given as the mean value of the analysed concentrations.
The TOC background of the blank water sample was maximum 1.3% compared to the lowest content of the test samples. It was considered not significantly affect the results of the test samples.
Main study - water solubility at a loading rate of 100 g/L
Loading rate |
Stirring time |
Analysed concentration |
Mean |
Percentage to |
MD |
pH |
|
|
|
|
|
|
|
100 |
24 |
31.4 |
|
|
|
3.5 |
|
|
|
|
|
|
|
100 |
48 |
37.6 |
38.71 |
391 |
5.71 |
3.5 |
|
|
|
|
|
|
|
100 |
72 |
39.8 |
|
|
|
3.6 |
|
|
|
|
|
|
|
1 Obtained with the samples at 48 and 72 hours.
Main study - water solubility at a loading rate of 1:1 w/v
Loading rate |
Stirring time |
Analysed concentration |
Mean |
Percentage to |
MD |
pH |
|
|
|
|
|
|
|
1000 |
24 |
260 |
268 |
27 |
4.8 |
3.5 |
|
|
|
|
|
|
|
1000 |
48 |
273 |
|
|
|
3.5 |
|
|
|
|
|
|
|
1000 |
72 |
273 |
|
|
|
3.5 |
|
|
|
|
|
|
|
Description of key information
At a loading rate of 100 g dry mass/L :
38.7 g/L at 20 °C (corresponds to a water solubility percentage of 39%
of the dry substance).
At the maximum loading rate of 1000 g dry mass/L :
268 g/L at 20 °C (corresponds to a water solubility percentage of 27% of
the dry substance).
Not completely soluble in water since in all samples undissolved test
substance particles were observed.
Key value for chemical safety assessment
Additional information
Water solubility is derived from a test with Vinasses, residue of fermentation containing biomass of Corynebacterium glutamicum according to OECD Guideline 105, flask method.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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