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Diss Factsheets
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EC number: 293-927-7 | CAS number: 91648-65-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Stability in organic solvents and identity of relevant degradation products
Administrative data
- Endpoint:
- stability in organic solvents and identity of relevant degradation products
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2012-03-21 - 2012-05-23
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- GLP guideline study, however no analysis was carried out to determine the homogeneity, concentration or stability of the test item formulations. The test item was formulated within two hours of being administered; it is assumed that the formulation was stable for this duration. This exception is considered not to affect the purpose or integrity of the study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: The study was performed according to the Study Plan and was designed to provide information for further repeated dose toxicity studies.
- Principles of method if other than guideline:
- The test item was administered by gavage to three groups, each of three male and three female Wistar Han™:RccHan™:WIST strain rats, for fourteen consecutive days, at dose levels of 50, 250 and 1000 mg/kg bw/day. A control group of three males and three females was dosed with vehicle alone (Arachis oil BP).
- GLP compliance:
- yes (incl. QA statement)
Test material
- Test material form:
- other: Liquid
- Details on test material:
- - Name of test material (as cited in study report): 1,3,4-Thiadiazolidine-2,5-dithione, reaction products with hydrogen peroxide and tert-nonanethiol
- Physical state: Liquid
- Expiration date of the lot/batch: 2013-09-05
- Storage condition of test material: Room temperature in the dark
- Other:
Description: Amber coloured liquid
Label: Performance Additive (1,3,4-Thiadiazolidine-2,5-dithione, reaction products with hydrogen peroxide and tert-nonanethiol)
For the purpose of this study, the test item was prepared at the appropriate concentrations as a solution in Arachis oil BP.
The test item was formulated within two hours of it being administered. It is assumed that the formulation was stable for this duration.
Constituent 1
Results and discussion
- Test substance stable:
- yes
- Transformation products:
- not measured
Applicant's summary and conclusion
- Conclusions:
- Observation during an experimental result from a repeated dose study (14-days, oral route, rats). The test substance was found to be stable in Arachis oil BP.
- Executive summary:
The oral administration of 1,3,4-Thiadiazolidine-2,5-dithione, reaction products with hydrogen peroxide and tert-nonanethiol to rats by gavage, at dose levels of 50, 250 and 1000 mg/kg bw/day, did not result in any toxicologically significant effects in treated animals (Harlan, 2012). The 'No Observed Effect Level' (NOEL) was therefore considered to be 1000 mg/kg bw/day. The test substance was found to be stable in Arachis oil BP, which was used as vehicle.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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