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EC number: 293-927-7 | CAS number: 91648-65-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Feb/Mar 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Guideline study. No GLP compliance is claimed, however, the final report includes an audit and quality assurance inspections. The study was conducted using skin that had been abraded (care was taken so as to only penetrate the stratum corneum and not the dermis). This deviates from the current OECD Guideline 402, however, this is not considered to affect the outcome of the study as the test material resulted in an LD50 of > 2000 mg/kg.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- This study was conducted using skin that had been abraded (care was taken so as to only penetrate the stratum corneum and not the dermis). However, this will not affect the outcome of the study.
- GLP compliance:
- no
- Remarks:
- The final report includes an audit and quality assurance inspections.
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Test material form:
- not specified
- Details on test material:
- - Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.0 to 2.4 kg
- Fasting period before study: No
- Housing: Individually housed in stainless steel cages (61.0 x 45.5 x 42.0 cm)
- Diet: Rabbits were fed Purina Rabbit Chow Complete Blend (Ralston Purina Co.) ad libitum
- Water: ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): approx. 22
- Humidity (%): approx. 40 (relative)
- Photoperiod (hrs dark / hrs light): 12 / 12
IN-LIFE DATES:
From 19 February 1981 to 6 March 1981
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: An area of 240 cm2 on the back of each animal
- Type of wrap if used: gauze pad and plastic film covered by towelling
REMOVAL OF TEST SUBSTANCE
- Washing (if done): skin washed clean of excess test material (solvent not reported)
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg
- Concentration (if solution): applied undiluted
- Constant volume or concentration used: yes - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 male and 5 female
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations were performed at least once a day; animals were weighed immediately prior to dosing
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- No statistical methods used.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortalities occured during the study.
- Clinical signs:
- other: One male rabbit had diarrhoea on days 2, 3 and 4, as did one female rabbit on day 3. This female and a different male rabbit had diarrhoea (immediately prior to dosing). All rabbits appeared normal on day 5 and for the remainder of the observation period.
- Gross pathology:
- No abnormal findings noted.
- Other findings:
- No other findings are reported.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The test report describes a valid guideline study, with auditation and quality assurance inspections of the final report. The acute dermal LD50 was determined to be greater than 2000 mg/kg. Thus, the test substance can be considered as not acutely toxic via the dermal route.
- Executive summary:
An acute dermal study was conducted using a similar procedure to that described in the current OECD Guideline 402 (Reckers, 1981). The test material (CAS No. 91648-65-6) was applied at a dose of 2000 mg/kg to the backs of five male and five female rabbits. The test item was left in contact with the skin for 24 hours and then the test sites were washed and the rabbits observed during this time and for 14 days after its removal. One male rabbit had diarrhea on days 2, 3 and 4, as did one female rabbit on day 3. This female and a different male rabbit had diarrhea (immediately prior to dosing). All rabbits appeared normal on day 5 and for the remainder of the observation period. Therefore this finding probably is not treatment related. There were no mortalities during the study and gross necropsy findings in all rabbits were within normal limits. The acute dermal LD50 was determined to be greater than 2000 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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