Registration Dossier
Registration Dossier
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EC number: 211-892-8 | CAS number: 706-14-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
German standard guideline DIN 38412 part 15 (similar to OECD 203), no GLP, key study, validity 2:
96h-LC50 = 21.5 mg/L
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 21.5 mg/L
Additional information
One valid key study is available to assess the acute toxicity of γ-decalactone on golden orfe (Leuciscus idus L.). This study was performed according to German standard guideline DIN 38412, part 15.
Based on the results of a range finding study, the concentrations, spaced by a factor of about 2.2 were fixed as follows: 10.0, 21.5, 46.4 and 100 mg/L (with one control). 10 animals were introduced per test vessels (all-glass aquarium) corresponding to a loading of 4.0 g fish/L test water.
Mortality and symptoms were recorded during the test and the mean lethal concentration (LC50) was determined using the probit analysis. The results show an LC50 after 96h of exposition at about 21.5 mg/L.
In conclusion, the 96h-LC50 at 21.5 mg/L was used for the chemical safety assessment.
Three other data are available to assess the short-term toxicity to fish of three structurally similar compounds of aliphatic lactones: γ-nonalactone, γ-decalactone and γ-undecalactone. These data are not used to support the experimental fish study performed on γ-decalactone but are used to support the read-across strategy between these three substances, as mentionned in the Read-across Justification in Section 13.
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