Registration Dossier
Registration Dossier
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EC number: 213-926-7 | CAS number: 1067-25-0
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2022
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: for information on QMRF and QPRF please see attached documents.
- Principles of method if other than guideline:
- The result was obtained using an appropriate QSAR method (see attached QMRF and QPRF for details).
The model is the publicly available KOWWIN v1.68 program (USEPA 2011). KOWWIN is part of EPI Suite v4.1 and may be downloaded from http://www.epa.gov/oppt/exposure/pubs/episuite.htm. The model is based on fragment values. That is, the chemical structure is broken down into its constituent functional groups, and the contribution of each group toward the overall partition coefficient is calculated. The constants used within KOWWIN have been derived by SRC from a wide range of organic chemicals. The authors of this QMRF have carried out additional validation and found the method to be applicable organosilicon compounds, excluding di- and tri-alkoxysilanes.
USEPA 2011. KOWWIN v. 1.68, US EPA. 2011. Estimation Programs Interface Suite™ for Microsoft® Windows, v 4.10. United States Environmental Protection Agency, Washington, DC, USA. Available at http://www.epa.gov/oppt/exposure/pubs/episuite.htm. - GLP compliance:
- no
- Type of method:
- other: QSAR
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- -1.4
- Remarks on result:
- other: QSAR result; pH and temperature are not reported.
- Conclusions:
- A Log Kow of -1.4 was obtained for the substance using an appropriate calculation method. The result is considered to be reliable.
Reference
Description of key information
silanol hydrolysis product: -1.4 (QSAR)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -1.4
Additional information
A Log Kow value of -1.4 was obtained for the silanol hydrolysis product using an appropriate calculation method.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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