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EC number: 213-926-7 | CAS number: 1067-25-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Trimethoxy(propyl)silane (CAS No. 1067-25-0) hydrolyses rapidly in contact with water (DT50 = 2.6 h, QSAR) to form propylsilanetriol and methanol (CAS No. 67-56-1).
The ECHA guidance R.16 states that “for substances where hydrolytic DT50 is less than 12 h, environmental effects are likely to be attributed to the hydrolysis product rather than to the parent itself” (ECHA, 2016). The TGD (EC2003) and ECHA guidance R.16 (ECHA 2010) also suggests that in case the hydrolysis half-life is less than 12 h, the breakdown products, rather than the parent
substance, should be evaluated for aquatic toxicity.
Thus, the environmental fate assessment in this dossier is based on the hydrolysis products propylsilanetriol and methanol rather than on the parent substance.
Propylsilanetriol
Propylsilanetriol is characterized by high water solubility (1.0E+06 mg/L, QSAR), a vapour pressure of 0.285 Pa (QSAR) and a low log Kow of -1.4 (QSAR) and is not readily biodegradable. Thus, it is likely to preferentially distribute to the water compartment where it is expected to persist. However, bioaccumulation is not of concern based on its low log Kow of well below 3.
Methanol
Methanol is water miscible at 20 °C, exhibits a low log Kow (-0.82 to -0.64) but a considerably higher vapour pressure (12790 Pa at 20 °C). Methanol does not undergo hydrolysis and volatilization is not a significant removal process from the aquatic compartment. However, methanol is readily biodegradable and has a low potential for bioaccumulation, with experimentally determined BCF values of < 10 in fish. The overall short- and long-term aquatic toxicity of methanol, which has been extensively studied for a broad spectrum of aquatic species, is low. Based on the currently available knowledge, methanol is of low priority (OECD SIDS, 2004).
Reference
OECD, 2004: SIDS Initial Assessment Report for Methanol, SIAM 19, Berlin, Germany, 19-22 October 2004, Methanol, CAS 67-56-1
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