Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

genetic toxicity in vivo
Type of genotoxicity: other: in vivo: DNA binding assay and DNA covalent binding in mouse liver
Type of information:
Adequacy of study:
supporting study
Study period:
Rationale for reliability incl. deficiencies:
other: Short description on comprehensive studies available via the internet by US EPA and

Data source

Reference Type:
secondary source
lactofen - Compound Summary (CID 62276)
US EPA and Pubchem NCBI
Bibliographic source:,3,31,7,12,25:p3_xchemical_id:2666

Materials and methods

Principles of method if other than guideline:
short summary on different studies
Type of assay:
other: In vitro: Salmonella typhimurium/mammalian microsome mutagenicity assay, mammalian cytogenetic assay and unscheduled DNA synthesis,

Test material

Constituent 1
Chemical structure
Reference substance name:
EC Number:
Cas Number:
Molecular formula:
Test material form:
not specified
Details on test material:
no data

Test animals

other: short summary on different experiments
not specified
not specified

Administration / exposure

Route of administration:
other: in vitro / in vivo studies


Tissues and cell types examined:
see summary

Results and discussion

Any other information on results incl. tables

The guideline and non-guideline studies indicate that lactofen is neither genotoxic nor mutagenic.

Applicant's summary and conclusion

Interpretation of results (migrated information): negative
Executive summary:

Executive summary is derived from the following internet links on 2012 -11 -09.

References of individual studies:

PPG Industries. 1985b. MRID No. 00132883, 00150329. Available from EPA. Write to FOI, EPA, Washington, DC 20460.

• /GENOTOXICITY/ The guideline and non-guideline studies indicate that lactofen is neither genotoxic nor mutagenic. Equivocal (probably negative) results were observed in an in vivo DNA binding assay with radiolabeled lactofen. Salmonella typhimurium/mammalian microsome mutagenicity assay: negative with and without S-9. In vitro cytogenetic assay with Chinese hamster ovary (CHO) cells: negative for clastogenic effects with and without S-9. In vitro unscheduled DNA synthesis in primary mouse and rat hepatocytes: negative. In vivo DNA covalent binding in mouse liver: low level of binding (equivocal, probably negative).