Registration Dossier
Registration Dossier
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EC number: 800-182-9 | CAS number: 1426148-68-6
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study planned
- Justification for type of information:
- TESTING PROPOSAL ON VERTEBRATE ANIMALS
NON-CONFIDENTIAL NAME OF SUBSTANCE:
- C6-C8-(even numbered, linear)-ethoxylated (<2.5 EO) (CAS 1426148-68-6)
CONSIDERATIONS THAT THE GENERAL ADAPTATION POSSIBILITIES OF ANNEX XI OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION [please address all points below]:
- Available GLP studies: not available
- Available non-GLP studies: not available
- Historical human/control data: not available
- (Q)SAR: not suitable
- In vitro methods: not suitable
- Weight of evidence: not possible since category approach can not be performed
- Grouping and read-across: not possible since category approach can not be performed
CONSIDERATIONS THAT THE SPECIFIC ADAPTATION POSSIBILITIES OF ANNEXES VI TO X (AND COLUMN 2 THEREOF) OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION:
- The substance is not known as genotoxic carcinogen, mutagenic, or obtains low toxicity with proven lack of exposure based on toxicokinetic data. Therefore, the study needs to be performed.
Data source
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 414 (Prenatal Developmental Toxicity Study)
Test material
- Reference substance name:
- Alcohols, C6-C8-(even numbered, linear)-ethoxylated (<2,5 EO)
- EC Number:
- 800-182-9
- Cas Number:
- 1426148-68-6
- Molecular formula:
- R-O-R' , whereas R=C6-8-(even numbered, linear, saturated)-alkyl and R'=H or xEO wheras x=1-12, mean=2,3
- IUPAC Name:
- Alcohols, C6-C8-(even numbered, linear)-ethoxylated (<2,5 EO)
- Test material form:
- liquid
- Details on test material:
- Chemical Name (IUPAC): Alkyl polyglycol ether; Alcohols, C6-8-alkyl-(even numbered), ethoxylated (˂2.5EO)
CAS No.: 1426148-68-6
Physical appearance (with color): Clear liquid
Based on the qualitative and quantitative information on the composition, the sample used is representative of the boundary composition.
Constituent 1
Test animals
- Species:
- rat
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
