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Diss Factsheets
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EC number: 203-472-8 | CAS number: 107-20-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity Profile of Chloroacetaldehyde
- Author:
- W.H. Lawrence, E.O. Dillingham, J.E. Turner, J. Autian
- Year:
- 1 972
- Bibliographic source:
- Journal of Pharmaceutical Sciences, Vol. 61, No. 1, Jan. 1972
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 8- 12 animals / group, only male rats were tested
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Chloroacetaldehyde
- EC Number:
- 203-472-8
- EC Name:
- Chloroacetaldehyde
- Cas Number:
- 107-20-0
- Molecular formula:
- C2H3ClO
- IUPAC Name:
- 2-chloroacetaldehyde
- Reference substance name:
- Chloroacetaldeyhde
- IUPAC Name:
- Chloroacetaldeyhde
- Test material form:
- other: solution in water
- Details on test material:
- 30% solution in water, purity not reported.
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 12 weeks
- Frequency of treatment:
- 3 times a week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.32 / 0.8 / 1.6 / 3.2 µL/kg, calculated as pure substance.
Applied as 0,5 % solution.
- No. of animals per sex per dose:
- 12 / 8 animals per group, only one sex used.
- Control animals:
- yes, concurrent vehicle
Results and discussion
Results of examinations
- Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- significant decrease
- Haematological findings:
- effects observed, treatment-related
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Details on results:
- Weight gain: significant decrease for the 2 higher dose groups.
Hematology at the end of study: no effect in the two lower dose groups. At 1.6 uL/kg decrease in erythrocytes and lymphocytes; increase in segmented neutrophils, increase in bromosulphophthalein clearance. At 3.2 uL/kg decrease in erythrocytes and hemoglobin, increase in neutrophils and in clotting time.
Histopatholgy: no dose-related effect on the relative organ weight, focal, chronic bronchopneumonia of the lungs, more pronounced for the two higher dose groups. Changes of respiratory epithelia suggesting preneoplastic lesions at the two higher dose groups.
Effect levels
- Dose descriptor:
- NOEC
- Effect level:
- ca. 0.8 other: µL/kg
- Based on:
- test mat.
- Sex:
- male
- Basis for effect level:
- other: Weight gain, hematology, histopathology
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- No or only minor observations in the two lower dose groups; weight gain and hematology effects in the two higher dose groups. Histopathologic effects were not dose-related.
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