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EC number: 242-533-3 | CAS number: 18721-51-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Oral:
LD50 cut-off = 370 mg/kg bw Trinickel dicitrate
Dermal:
LD50 > 1480 mg/kg bw Trinickel dicitrate
Key value for chemical safety assessment
Acute toxicity: via dermal route
Endpoint conclusion
- Value:
- mg/kg bw
Additional information
Oral
The oral acute toxicity study has been performed according to OECD guideline 423. First, groups of 6 female Sprague Dawley rats received a single oral dose of 2000 mg/kg bw nickel hydrogencitrate (recalculated for Trinickel dicitrate: 1480). All animals died within 72 hours after dosing. Mortalities were preceded by a decrease in spontaneous activity associated with partial ptosis, piloerection and bradypnea as well as a decrease in muscle tone and righting reflex. Furthermore, increased lachrymation was observed. In a second step, 6 female rats of the same strain were dosed with 300 mg/kg bw nickel hydrogencitrate. No animal died. At this dose level, there were no effects related to treatment. The LD50 cut-off was determined as 500 mg/kg bw nickel hydrogencitrate. (recalculated for Trinickel dicitrate: 370)
Inhalation
No reliable acute study public available.
Dermal
For the dermal route, a study according to OECD guideline 402 has been performed with nickel hydrogencitrate in 5 Sprague Dawley rats of each sex at a single dose of 2000 mg/kg bw. No mortality occured. There were no treatment-related effects. Therefore, the LD50 was determined as higher than 2000 mg/kg bw (recalculated for Trinickel dicitrate: 1480).
Remark:
Nickel hydrogencitrate and Trinickel dicitrate are comparable: Since citric acid is a multifunctional acid, at different pH values various intermediate ions like citrate, hydrogencitrate and dihydrogencitrate are formed.
[citric acid, nickel salt] is present on the surface of an inert carrier material (aluminium oxide). Depending on the pH value to prepare the impregnation solution or present while impregnation different molar ratios between nickel and citric acid are possible.
For this reason the concentrations of the single Nickel constituents of [citric acid, nickel salt] are various. The calculated values refer to the constituent Trinickel dicitrate and have to seen as a lower threshold value.
Justification for classification or non-classification
Based on the available data, the substance [citric acid, nickel salt] needs to be cassified:
Oral
EU: R22 Harmful if swallowed.
CLP: Category 4
Inhalation:
There is conclusive data available which is not sufficient for classification.
Dermal
There is conclusive data available which is not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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