Ammonium bromide

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2000

Reliability:

1 (reliable without restriction)

Qualifier:

according to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

GLP compliance:

yes

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide.

Analytical monitoring:

no

Details on sampling:

Dissolved oxygen, pH and temperature were measured and recorded immediately before and after daily test media renewal in each test chamber.

Vehicle:

no

Details on test solutions:

Artificial seawater (Coral Reef, Kent Sea Salt, Red Sea Fish Pharm)

Test organisms (species):

other: Scophthalmus maximus (Juvenile turbot)

Details on test organisms:

Species/strain: Juvenile turbot (Scophthalmus maximus)
Source: Mannin Sea Farms, Derbyhaven, Isle of Man
Wild caught: No
Age: not stated
Size: 3.6 cm (3.3 - 3.9 cm)
Weight: 0.78 g (0.62 – 0.95 g)
Feeding frequency: fish fed until 24 hours prior to the start of the test.
Pretreatment: Fish held for unspecified period at 15 ± 2 °C in aerated water.

Test type:

semi-static

Water media type:

saltwater

Limit test:

no

Total exposure duration:

96 h

Post exposure observation period:

no further details

Hardness:

Not stated

Test temperature:

14.2-15.7 degree C

pH:

8.06-8.29

Dissolved oxygen:

91.4-97.6%

Salinity:

Not stated

Nominal and measured concentrations:

0, 100, 177.8, 316.2, 562.3, 1000 mg/L nominal

Details on test conditions:

Renewal of test solution Once daily
Volume of test vessels 10 litres
Volume/animal 1.4 litres per fish
Number of animals/vessel 7 fish per vessel
Number of vessels/ concentration 1
Test performed in closed vessels due to significant volatility of TS No
Adjustment of pH No
Aeration of dilution water Yes – air bubbled directly into test media
Intensity of irradiation Ambient laboratory lighting
Photoperiod 10 h photoperiod daily

Reference substance (positive control):

no

Duration:

96 h

Dose descriptor:

NOEC

Effect conc.:

>= 440 mg/L

Nominal / measured:

nominal

Basis for effect:

other: Cessation of movement and failure to respond to tactile stimulation

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 440 mg/L

Nominal / measured:

nominal

Basis for effect:

other: Cessation of movement and failure to respond to tactile stimulation

Details on results:

No futher details

Results with reference substance (positive control):

No futher details

Reported statistics and error estimates:

The mortality data calculated at each observation period is usually processed using the statistical computer programme Toxcalc, supplied by Tidepool Scientific (STL Runcorn SOP V.1). Toxcalc is used to derive the median effect concentration (LC50) which kills (immobilises) 50% of the animals exposed to the test material, together with 95% fiducial limits and a No Observed Effect Concentration (NOEC). However, the data were deemed unsuitable for such analysis in this case.

Sublethal observations / clinical signs:

Result are quoted for pure sodium bromide, i.e. corrected given the concentration of sodium bromide in the initial solution Test result is equivalent to: LC50 >342 mg(Br-)/L for the bromide ion

Validity criteria fulfilled:

yes

Conclusions:

The acute toxicity of sodium bromide solution to Juvenile turbot (Scophthalmus maximus) over 96 h under semi-static conditions with 5 concentrations of test substance was assessed according to OECD Guideline 203.
No mortality or other adverse effects were noted due to the administration of the test substance.
The LD50 (96 h) is stated as <1000.0 mg/L NaBr solution.
The NOEC (96 h) is stated as <1000.0 mg/L NaBr solution.

Executive summary:

LC50(48h) >1000.0 (n) Equivalent to: >440 mg (NaBr)/L >342 mg (Br-)/L

LC50(96h) >1000.0 (n) Equivalent to: >440 mg (NaBr)/L >342 mg (Br-)/L

Reference 2

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1981

Reliability:

2 (reliable with restrictions)

Qualifier:

no guideline available

Principles of method if other than guideline:

No guideline available

GLP compliance:

no

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide.

Analytical monitoring:

no

Details on sampling:

Not stated

Vehicle:

no

Details on test solutions:

The study was performed and published by Dow Chemical Company, but the method refers to an internal method, 1978.

Test organisms (species):

Pimephales promelas

Details on test organisms:

Criteria Details
Species/strain Fathead Minnows
Source US EPA Laboratory, Duluth, MN
Wild caught No
Age/size Age: approx 75 days old
Kind of food Specially formulated diet mix
Amount of food Ad libitum
Feeding frequency Once or twice daily
Pretreatment Acclimation to test temperature
Feeding of animals during test No

Test type:

static

Limit test:

yes

Total exposure duration:

96 h

Post exposure observation period:

no further details

Hardness:

95-134 mg/L as CaCO3

pH:

7.6-8.1

Dissolved oxygen:

Not stated

Salinity:

not stated

Nominal and measured concentrations:

20000, 18000, 16200, 14580, 13122, 11810, 10629, 9566 and 8610 mg/L

Details on test conditions:

Criteria Details
Test type Static
Renewal of test solution N/A
Volume of test vessels 10 L
Volume/animal 1 L per animal
Number of animals/vessel 10 animals per vessel
Number of vessels/ concentration 1
Test performed in closed vessels due to significant volatility of TS No
Criteria Details
Test temperature 12 ± 1 °C
Dissolved oxygen Not stated
pH Not stated
Adjustment of pH Not stated
Aeration of dilution water Yes for 24h prior to addition of test material
Intensity of irradiation 915-1345 lux cool white fluorescent illumination
Photoperiod 16 h photoperiod daily

Reference substance (positive control):

no

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

16 479 mg/L

Nominal / measured:

nominal

Details on results:

no further details

Results with reference substance (positive control):

no further details

Reported statistics and error estimates:

Calculation of LC50 was performed using Finney’s method of probit analysis, Thompson’s method of moving averages and the binomial method.

Sublethal observations / clinical signs:

Test result is equivalent to: LC50 = 12788 mg(Br-)/L for the bromide ion

Validity criteria fulfilled:

yes

Conclusions:

Fathead Minnows were exposed to the test material at 9 different concentrations ranging in a geometric series from 20000 to 8610 mg/L (10 fish per concentration) for 96 hours. The LC50 values appropriate for 48 and 96 hour exposures were calculated using probit analysis.
Mortality data is not given. For LC50 values see below. No sublethal effects were described.

Reference 3

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1988

Reliability:

1 (reliable without restriction)

Qualifier:

according to guideline

Guideline:

EPA OPP 72-1 (Fish Acute Toxicity Test)

GLP compliance:

yes

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide.

Analytical monitoring:

no

Details on sampling:

No further details

Vehicle:

no

Details on test solutions:

Criteria Details
Source Reconstituted water
Alkalinity 25-35 mg/L
Hardness 40-48 mg/L
pH 7.2-7.6
Oxygen content 9.5 mg/L
Conductance Not stated
Holding water different from dilution water No

Test organisms (species):

Lepomis macrochirus

Details on test organisms:

Criteria Details
Species/strain Bluegill sunfish (ABC Lot 6787)
Source Osage Catfisheries, Osage Beach
Wild caught No
Age/size Mean weight 0.24 (±0.072) g, mean length 23 (±2.0) mm
Age not stated
Kind of food Standard commercial fish food occasionally supplemented with brine shrimp nauplii (Artemia sp.)
Amount of food Not stated
Feeding frequency Daily
Pretreatment acclimation period of 14 days minimum
Feeding of animals during test No

Test type:

static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

96 h

Post exposure observation period:

no further details

Hardness:

40-48 mg/L

Test temperature:

21-22 degree C

pH:

7.2-7.6

Dissolved oxygen:

9.5 mg/L

Salinity:

Not stated

Nominal and measured concentrations:

0, 100, 180, 320, 560, 1000 mg/L nominal

Details on test conditions:

no further details

Reference substance (positive control):

no

Duration:

96 h

Dose descriptor:

NOEC

Effect conc.:

>= 1 000 mg/L

Nominal / measured:

nominal

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 1 000 mg/L

Nominal / measured:

nominal

Details on results:

no further details

Results with reference substance (positive control):

no further details

Reported statistics and error estimates:

no further details

Sublethal observations / clinical signs:

Test result is equivalent to: LC50 >776 mg(Br-)/L for the bromide ion

Validity criteria fulfilled:

yes

Conclusions:

The acute toxicity of sodium bromide to Bluegill sunfish (Lepomis macrochirus) over 96 h under static conditions with 5 concentrations of test substance was assessed according to US EPA-FIFRA, guideline 72-1.
No mortalities or other abnormal effects were observed in any of the dose groups. Therefore the 96 h LC50 is >1000 mg/L sodium bromide. A 95% confidence interval could not be established due to the lack of mortality/adverse effects seen at any of the doses used.
The 96 h NOEC was 1000 mg/L sodium bromide.

Reference 4

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1988

Reliability:

1 (reliable without restriction)

Qualifier:

according to guideline

Guideline:

EPA OPP 72-1 (Fish Acute Toxicity Test)

GLP compliance:

yes

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide.

Analytical monitoring:

no

Details on sampling:

Dissolved oxygen, pH and temperature were measured and recorded at 0, 24, 48 and 96 hours in each test chamber.

Vehicle:

no

Details on test solutions:

Criteria Details
Source Reconstituted water
Alkalinity 25-35 mg/L
Hardness 40-48 mg/L
pH 7.2-7.6
Oxygen content 9.4 mg/L
Conductance Not stated
Holding water different from dilution water No

Test organisms (species):

Oncorhynchus mykiss (previous name: Salmo gairdneri)

Details on test organisms:

Criteria Details
Species/strain Rainbow Trout (Salmo gairdneri)
Source Mt. Lassen Trout Farm, Red Bluff, California
Wild caught No
Age/size Mean weight 0.59 (±0.12) g, mean length 34 (±2.5) mm
Ages not stated
Kind of food Standard commercial fish food occasionally supplemented with brine shrimp nauplii (Artemia sp.)
Amount of food Not stated
Feeding frequency Daily until 48-96 hours prior to testing
Pretreatment acclimation period of 14 days minimum followed by fasting immediately (48-96 hrs) beforethe test began.
Feeding of animals during test No

Test type:

static

Water media type:

freshwater

Limit test:

yes

Total exposure duration:

96 h

Post exposure observation period:

no further details

Hardness:

40-48 mg/L

Test temperature:

12-13 degree C

pH:

7.2-7.6

Dissolved oxygen:

9.4 mg/L

Salinity:

no further details

Nominal and measured concentrations:

0, 100, 180, 320, 560, 1000 mg/L nominal

Details on test conditions:

no further deatils

Reference substance (positive control):

no

Duration:

96 h

Dose descriptor:

NOEC

Effect conc.:

320 mg/L

Nominal / measured:

nominal

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 1 000 mg/L

Nominal / measured:

nominal

Details on results:

no further details

Results with reference substance (positive control):

no further details

Reported statistics and error estimates:

Since no animals died, no statistical analysis of the LC50 was conducted. The LC50 was, therefore, estimated from the data

Sublethal observations / clinical signs:

Test result is equivalent to: LC50 >776 mg(Br-)/L for the bromide ion

Validity criteria fulfilled:

yes

Conclusions:

The acute toxicity of sodium bromide to Rainbow Trout (Salmo gairdneri) over 96 h under static conditions with 5 concentrations of test substance was assessed according to US EPA-FIFRA, guideline 72-1.
No mortalities were observed in any dose groups.
Therefore the 96 h LC50 is >1000 mg/L sodium bromide. A 95% confidence interval could not be established due to the lack of mortality seen at any of the doses used.
No abnormal effects were observed in the control and the 100, 180 and 320 mg/L dose groups.
Loss of equilibrium, dark discoloration, fish on the bottom of the test chamber and or quiescence were observed in the 560 and 1000 mg/L dose groups.
The 96 h NOEC is 320 mg/L sodium bromide.

Reference 5

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1979

Reliability:

4 (not assignable)

Principles of method if other than guideline:

Method: other: method in agreement with "concepts of the Dutch Standardisation Institute"

GLP compliance:

no

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide.

Test organisms (species):

other: various

Test type:

not specified

Dose descriptor:

LC50

Effect conc.:

13 000 - 20 000 mg/L

Sublethal observations / clinical signs:

Test result is equivalent to: LC50 = 10090-15530 mg(Br-)/L for the bromide ion

Reference 6

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1982

Reliability:

2 (reliable with restrictions)

Principles of method if other than guideline:

Method: other: Dutch Standardisation Organisation (1980; NEN 6501, 6502, 6504 & 6506)

GLP compliance:

no

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide.

Analytical monitoring:

no

Test organisms (species):

Poecilia reticulata

Test type:

semi-static

Limit test:

no

Duration:

96 h

Dose descriptor:

NOEC

Effect conc.:

0.032 g/L

Nominal / measured:

nominal

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

20.6 g/L

Nominal / measured:

nominal

Duration:

96 h

Dose descriptor:

LC0

Effect conc.:

10 g/L

Nominal / measured:

nominal

Duration:

96 h

Dose descriptor:

EC50

Effect conc.:

0.057 g/L

Nominal / measured:

nominal

Sublethal observations / clinical signs:

Test result is equivalent to: LC50 = 16.0 g(Br-)/L for the bromide ion

Reference 7

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1982

Reliability:

2 (reliable with restrictions)

Guideline:

other:

Principles of method if other than guideline:

Dutch Standardisation Organisation (1980; NEN 6501, 6502, 6504 & 6506)

GLP compliance:

no

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide.

Analytical monitoring:

no

Test organisms (species):

Oryzias latipes

Test type:

semi-static

Limit test:

no

Duration:

96 h

Dose descriptor:

NOEC

Effect conc.:

0.32 g/L

Nominal / measured:

nominal

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

30.9 g/L

Nominal / measured:

nominal

Duration:

96 h

Dose descriptor:

LC0

Effect conc.:

10 g/L

Nominal / measured:

nominal

Duration:

96 h

Dose descriptor:

EC50

Effect conc.:

0.57 g/L

Nominal / measured:

nominal

Sublethal observations / clinical signs:

Test result is equivalent to: LC50 = 24.0 g(Br-)/L for the bromide ion

Reference 8

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1991

Reliability:

4 (not assignable)

GLP compliance:

not specified

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide.

Test organisms (species):

Poecilia reticulata

Dose descriptor:

LC50

Effect conc.:

16 000 mg/L

Sublethal observations / clinical signs:

Test result is equivalent to: LC50 = 12410 mg(Br-)/L for the bromide ion

Reference 9

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1991

Reliability:

4 (not assignable)

GLP compliance:

not specified

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide.

Analytical monitoring:

not specified

Test organisms (species):

Oryzias latipes

Test type:

not specified

Dose descriptor:

LC50

Effect conc.:

24 000 mg/L

Sublethal observations / clinical signs:

Test result is equivalent to: LC50 = 18620 mg(Br-)/L for the bromide ion

Reference 10

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Qualifier:

no guideline followed

Principles of method if other than guideline:

No guideline followed

GLP compliance:

no

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide.

Analytical monitoring:

no

Test organisms (species):

Poecilia reticulata

Test type:

semi-static

Total exposure duration:

28 d

Duration:

28 d

Dose descriptor:

NOEC

Effect conc.:

32 mg/L

Nominal / measured:

nominal

Duration:

28 d

Dose descriptor:

LOEC

Effect conc.:

100 mg/L

Nominal / measured:

nominal

Sublethal observations / clinical signs:

Test result is equivalent to: NOEC = 24.8 mg(Br-)/L for the bromide ion

Reference 11

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1991

Reliability:

4 (not assignable)

GLP compliance:

no

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide.

Analytical monitoring:

not specified

Test organisms (species):

Cyprinus carpio

Test type:

other: fish were dosed by gavage or by intraperitoneal injection

Limit test:

no

Dose descriptor:

other: LD50(i.p.)

Effect conc.:

> 4 000

Dose descriptor:

other: LD50 (oral)

Effect conc.:

2 380

Sublethal observations / clinical signs:

Results are given as mg/kg bw Test results are equivalent to: LD50 (oral) = 1847 mg(Br-)/kg LD50 (i.p.) > 3104 mg(Br-)/kg for the bromide ion

Reference 12

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1991

Reliability:

4 (not assignable)

GLP compliance:

no

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide.

Test organisms (species):

other: nonpedigreed guppies from a warm water reservoir

Test type:

static

Limit test:

no

Duration:

24 h

Dose descriptor:

LC50

Effect conc.:

25 000 mg/L

Sublethal observations / clinical signs:

Test result is equivalent to: LC50 = 19400 mg(Br-)/L for the bromide ion

Description of key information

Sodium bromide is not considered toxic to fish based on the LC50 value of >440 mg/L found for Scophthalmus maximus in 96 hours. 

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Dose descriptor:

LC50

Effect concentration:

> 440 mg/L

Additional information

Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide.

Sodium bromide is not considered toxic to fish based on the LC₅₀value of >440 mg/Lfound for Scophthalmus maximus in 96 hours.