Ammonium bromide

Toxicity to other above-ground organisms

Link to relevant study record(s)

Reference

Endpoint:

toxicity to other above-ground organisms

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1983

Reliability:

2 (reliable with restrictions)

Qualifier:

no guideline available

Principles of method if other than guideline:

other

GLP compliance:

no

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide.

Analytical monitoring:

no

Details on sampling:

N.A.

Vehicle:

no

Details on preparation and application of test substrate:

no further details

Test organisms (species):

other: Xenopus laevis (Amphibian)

Details on test organisms:

Strain / Clone
Xenopus laevis
Source
Standardised laboratory culture
Age
<2 days
Kind of food
Neattle, powder, heart

Study type:

laboratory study

Limit test:

yes

Total exposure duration:

100 d

Post exposure observation period:

no further details

Test temperature:

19-21 degree C

Humidity:

not stated

Photoperiod and lighting:

circadic

Details on test conditions:

Test type: Semistatic
Renewal of test solution: Renewals performed every Monday, Wednesday and Friday
Volume of test vessels: 50 litre
Volume/animal: 667 mL per animal
Number of animals/vessel: 75 animals per vessel
Number of vessels/ concentration: 1
Test performed in closed vessels due to significant volatility of TS: No
Test temperature: 20 ± 1 °C
Quality/Intensity of irradiation: Lighting described as circadic
Photoperiod: Lighting described as circadic

Nominal and measured concentrations:

Nominal concentrations used differed by a factor of √10. Test concentrations included 32 and 320 mg/L. Full range tested was not stated.

Reference substance (positive control):

no

Duration:

100 d

Dose descriptor:

other: LOEC

Effect conc.:

32 other: mg/L

Basis for effect:

mortality

Details on results:

no further details

Results with reference substance (positive control):

no further details

Reported statistics and error estimates:

Not stated

Test result is equivalent to: NOEC = 24.8 mg(Br-)/L for the bromide ion

Validity criteria fulfilled:

no

Conclusions:

Xenopus laevis amphibians were exposed to sodium bromide (concentration range not specified) in test waters for 100 days in a semi-static toxicity test. Observations of mortality, development and growth were used to determine the LOEC and NOEC values.
Individual sub lethal effects and mortality data were not given. The lowest 100 day NOEC was found to be 32 mg/L NaBr based on mortality.
None of the validity criteria can be considered as fulfilled, see validity criteria summarized in table A7_4_3_5-6, however this is due to the fact that insufficient data was presented in order to assess any of the criteria.

Description of key information

Xenopus laevis amphibians were exposed to sodium bromide in test waters for 100 days in a semi-static toxicity test. Observations of mortality, development and growth were used to determine the LOEC and NOEC values. The lowest 100 day NOEC was found to be 32 mg/l sodium bromide based on mortality.

Additional information

Ammonium bromide is an inorganic salt that dissociates to its composite ions in aqueous solutions at environmental pH and temperature. Comparison of the available data on the various bromide salts have shown that the bromide ion is the relevant ion for determination of the toxicological profile with simple cations such as potassium, sodium or ammonium, that are ubiquitous in nature, having little or no influence on the bromide ion properties. It is therefore justified to read-across data from other inorganic bromide salts to ammonium bromide.

Xenopus laevis amphibians were exposed to sodium bromide in test waters for 100 days in a semi-static toxicity test. Observations of mortality, development and growth were used to determine the LOEC and NOEC values. The lowest 100 day NOEC was found to be 32 mg/l sodium bromide based on mortality.