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Diss Factsheets
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EC number: 207-306-5 | CAS number: 460-19-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 960
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Humans were exposed to the gas in the sealed room. Ages ranged from 21 to 65 years, and all were in good health except one who had mild cold symptoms.
- GLP compliance:
- no
Test material
- Reference substance name:
- Oxalonitrile
- EC Number:
- 207-306-5
- EC Name:
- Oxalonitrile
- Cas Number:
- 460-19-5
- Molecular formula:
- C2N2
- IUPAC Name:
- carbononitridic cyanide
- Test material form:
- gas
Constituent 1
- Specific details on test material used for the study:
- 99.5 %
Test animals / tissue source
- Species:
- human
- Details on test animals or tissues and environmental conditions:
- Humans were exposed to the gas in the sealed room. Ages ranged from 21 to 65 years, and all were in good health except one who had mild cold symptoms.
Test system
- Vehicle:
- other: air
- Amount / concentration applied:
- a) 8 ppm for 6 minutes
b) 16 ppm for 6 and 8 minutes - Duration of treatment / exposure:
- a) 8 ppm for 6 minutes
b) 16 ppm for 6 and 8 minutes - Observation period (in vivo):
- a) 8 ppm for 6 minutes
b) 16 ppm for 6 and 8 minutes - Number of animals or in vitro replicates:
- a) 8 ppm for 6 minutes - three males and two females
b) 16 ppm for 6 and 8 minutes - four males and three females
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 0 <=
- Max. score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 0 <=
- Max. score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 0 <=
- Max. score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 0 <=
- Max. score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- In human volunteers, no irritation was observed during a 6-min exposure to 18 mg/m3 (8 ppm) while eye and nasal irritation (exhibited by lacrimation – no damage observed) were experienced at 35 mg/m3 (16 ppm).
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP criteria not met
- Conclusions:
- Data on humans and rats indicate that ethanedinitrile can cause nasal and/or eye irritation. In human volunteers, no irritation was observed during a 6-min exposure to 18 mg/m3 (8 ppm) while eye and nasal irritation (exhibited by lacrimation – no damage observed) were experienced at 35 mg/m3 (16 ppm).
- Executive summary:
Data on humans and rats indicate that ethanedinitrile can cause nasal and/or eye irritation. In human volunteers, no irritation was observed during a 6-min exposure to 18 mg/m3 (8 ppm) while eye and nasal irritation (exhibited by lacrimation – no damage observed) were experienced at 35 mg/m3 (16 ppm) (Table 1).
Table 1: Irritation effect of ethanedinitrile upon human subjects
Ethanedinitrile concentration (ppm)
Exposure time (minutes)
No. of subjects
No. of subjects experiencing effects
Irritation
Eye
Nasal
8
6
7
0
0
16
6
5
5
4
16
8
7
7
7
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