Registration Dossier
Registration Dossier
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EC number: 207-306-5 | CAS number: 460-19-5
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 960
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Available studies provide sufficient evidence that ethanedinitrile does not have skin sensitisation properties. Therefore LLNA study was not conducted
- GLP compliance:
- no
- Type of study:
- not specified
- Justification for non-LLNA method:
- Available studies provide sufficient evidence that ethanedinitrile does not have skin sensitisation properties. Therefore LLNA study was not conducted
Test material
- Reference substance name:
- Oxalonitrile
- EC Number:
- 207-306-5
- EC Name:
- Oxalonitrile
- Cas Number:
- 460-19-5
- Molecular formula:
- C2N2
- IUPAC Name:
- carbononitridic cyanide
- Test material form:
- gas
Constituent 1
- Specific details on test material used for the study:
- ethanedinitrile 99.5 %
In vivo test system
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Remarks:
- albino rabbits
- Sex:
- male
Study design: in vivo (LLNA)
- Vehicle:
- unchanged (no vehicle)
- Concentration:
- 10000 ppm
- No. of animals per dose:
- 4
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Value:
- 10 000
- Test group / Remarks:
- 4
- Parameter:
- SI
- Remarks:
- Dermal exposure of rabbits to 10,000 ppm (~21 g/m3) of ethanedinitrile for eight hours, did not result in any clinical observations or macroscopic effects.
- Value:
- 10 000
- Test group / Remarks:
- 4
Any other information on results incl. tables
Available studies provide sufficient evidence that ethanedinitrile does not have skin sensitisation properties.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP criteria not met
- Conclusions:
- Dermal exposure of rabbits to ethanedinitrile gas in an acute toxicity study indicates that ethanedinitrile is not a skin sensitiser. Dermal exposure of rabbits to 10,000 ppm (~21 g/m3) of ethanedinitrile for eight hours, did not result in any clinical observations or macroscopic effects.
- Executive summary:
Dermal exposure of rabbits to ethanedinitrile gas in an acute toxicity study indicates that ethanedinitrile is not a skin sensitiser. Dermal exposure of rabbits to 10,000 ppm (~21 g/m3) of ethanedinitrile for eight hours, did not result in any clinical observations or macroscopic effects.
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