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Diss Factsheets
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EC number: 256-170-3 | CAS number: 44914-03-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
LD50 (Acute Oral Rat): 3.5 ml/kg (3150 mg/kg)
LC50 (Inhalation 4 hr Rat, Male and Female): 10.3 mg/l (1970 ppm)
RD50 (Inhalation 30 minute Mouse Male): 1.78 mg/l (340 ppm)
LD50 (Acute Dermal Rabbit): 2000 mg/kg
LD50 (Acute Dermal Rabbit) 3024 mg/kg
Key value for chemical safety assessment
Additional information
Acute Oral Toxicity: One study has been cited in secondary source literature for the source chemical n-butyl acrylate. The results are considered to be appropriate for the target chemical 2-methy acrylate. The LD50 is 3150 mg/kg.
Acute Inhalation Toxcity: Two acute inhalation studies have been conducted on the analog source n-butyl acrylate. The acute toxicity test resulted in an overall 4 hr LC50 for males and females of 10.3 mg/l. The LC50 for males was 11.2 mg/l and the LC50 for females was 10 mg/l. These are measured concentrations. An overall 1 hour LC50 for males and females was 41.2 mg/l or 7860 ppm.
An Airway Irritation/Respiratory Depression (RD50) Study of the analog source n-butylacrylate was conducted on male mice. This study resulted in an RD50 of 1.78 mg/l (340 ppm). An LOEL of 052 mg/l (100 ppm) was noted. The NOEL was 0.16 mg/l (30) ppm)
Acute Dermal Toxicity:
Two studies have been cited in secondary source literature for the source chemical n-butyl acrylate. The results are considered to be appropriate for the target chemical 2-methylbutyl acrylate. The LD50 values are 2000 mg/kg and 3024 mg/kg. There is no reason to select one value in favor of the other and the LD50 value is determined to be between 2000 mg/kg and 3024 mg/kg.
Data matrix – Analog approach |
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Target substance |
Source substance (1) |
|
|
CHEMICAL NAME |
2-methylbutyl acrylate |
n-butyl acrylate |
|
CAS# |
44914-03-6 |
141-32-2 |
|
Molecular formula |
C8H14O2 |
C7H12O2 |
|
Molecular Weight |
142.2 |
128.2 |
|
PHYSICO-CHEMICAL DATA |
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Melting Point |
Experimental: ≤ -75 °C |
Not available |
|
Boiling Point |
Experimental: 161.7 °C at 1013hPa |
Experimental: 147 °C at 1013hPa |
|
Density |
Experimental: 0.8886 g/cm3 at 25 °C |
Experimental: 0.9 g/cm3 at 20.0 °C |
|
Vapour Pressure |
Experimental: 1.7 hPa at 20°C |
Experimental: 5 hPa at 22.2°C |
|
Partition Coefficient (log KOW) |
Experimental: 2.9 |
Experimental: 2.38 (at 25°C) |
|
Water Solubility |
Experimental: 316 mg/L at 23 °C |
Not available |
|
MAMMALIAN TOXICITY |
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Acute Oral Toxicity |
Readacross from source (1): 3150 mg/kg |
Experimental: 3150 mg/kg |
|
Acute Dermal Toxicity |
Readacross from source (1): 2000-3000 mg/kg |
Experimental: 2000 -3000 mg/kg |
|
Acute Inhalation Toxity |
Readacross from source (1): 1970 ppm |
Experimental: 1970 ppm |
|
Justification for classification or non-classification
The acute inhalation LC50 of 340 ppm results in a GHS and CLP classification of Acute Tox 4. The DSD classification is Xn R20.
Criteria for acute dermal and oral toxicity are not met by the data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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