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Diss Factsheets
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EC number: 256-170-3 | CAS number: 44914-03-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on developmental toxicity
Additional information
In study #1, no effects on reproductive organs of either sex were reported at the highest dose tested.
In study #2, no pathology was attributed to the test substance. In the mid- and high-dose groups(135 and 250 ppm), the percentage of live implantations was decreased in a dose-dependent manner and the number of resorptions was increased. No treatment related malformations , skeletal abnormalities or organ changes were seen in the fetuses at any concentration.
In study #3, no test substance related effects were seen in the number of implantation sites, live fetuses, non-live implants or resorptions. Fetal body weights were reduced in the mid- and high-dose (200 and 300 ppm) groups. No treatment related effects were seen on the incidence of external and internal variations and the incidence of skeletal variations was similar in the control and treated groups.
In study #4, a reduction in body fetal body weight was seen at doses above 1500 mg/kg; resorptions were increased above 2500 mg/kg. In the control, 100 mg/kg, 1000 mg/kg, 1500 mg/kg and 2000 mg/kg variations and malformations occurred sproradically and on different sides in a non-dose-dependent manner. In the higher dose groups, 2500 mg/kg and 3000 mg/kg, the number of fetuses with external and skeletal malformations was significantly increased.
Data matrix – Analog approach |
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Target substance |
Source substance (1) |
|
|
CHEMICAL NAME |
2-methylbutyl acrylate |
n-butyl acrylate |
|
CAS# |
44914-03-6 |
141-32-2 |
|
Molecular formula |
C8H14O2 |
C7H12O2 |
|
Molecular Weight |
142.2 |
128.2 |
|
PHYSICO-CHEMICAL DATA |
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Melting Point |
Experimental: ≤ -75 °C |
Not available |
|
Boiling Point |
Experimental: 161.7 °C at 1013hPa |
Experimental: 147 °C at 1013hPa |
|
Density |
Experimental: 0.8886 g/cm3 at 25 °C |
Experimental: 0.9 g/cm3 at 20.0 °C |
|
Vapour Pressure |
Experimental: 1.7 hPa at 20°C |
Experimental: 5 hPa at 22.2°C |
|
Partition Coefficient (log KOW) |
Experimental: 2.9 |
Experimental: 2.38 (at 25°C) |
|
Water Solubility |
Experimental: 316 mg/L at 23 °C |
Not available |
|
MAMMALIAN TOXICITY |
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Reproductive Effects |
Readacross from source (1): NOAEC for effects on reproductive organs: 546 ppm (highest dose tested) |
Experimental: NOAEC for effects on reproductive organs: 546 ppm (highest dose tested) |
|
Developmental/Teratogenicity Study in Rats via inhalation |
Readacross from source (1): NOAEC embryotoxicity: 25 ppm NOAEC maternal toxicity: 25 ppm NOAEC teratogenicity: 250 ppm |
Experimental: NOAEC embryotoxicity: 25 ppm NOAEC maternal toxicity: 25 ppm NOAEC teratogenicity: 250 ppm |
|
Developmental/Teratogenicity Study in Rats via inhalation |
Readacross from source (1): LOAEC maternal toxicity: 100 ppm NOAEC fetotoxicity: 100 ppm NOAEC teratogenicity: 300 ppm |
Experimental: LOAEC maternal toxicity: 100 ppm NOAEC fetotoxicity: 100 ppm NOAEC teratogenicity: 300 ppm |
|
Developmental Toxicity Study in mice via oral gavage |
Readacross from source (1): NOAEL Maternal Toxicity: 100 mg/kg NOAEL Developmental Toxicity: 1000 mg/kg NOAEL Teratogenicity: 2000 mg/kg |
Experimental: NOAEL Maternal Toxicity: 100 mg/kg NOAEL Developmental Toxicity: 1000 mg/kg NOAEL Teratogenicity: 2000 mg/kg |
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Justification for classification or non-classification
The data do not support the classification as a reproductive or developmental substance.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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