Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-237-5 | CAS number: 2680-03-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Near-guideline study, available as published report, no restrictions, fully adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- N,N-dimethylacrylamide
- EC Number:
- 220-237-5
- EC Name:
- N,N-dimethylacrylamide
- Cas Number:
- 2680-03-7
- Molecular formula:
- C5H9NO
- IUPAC Name:
- N,N-dimethylacrylamide
- Details on test material:
- - Name of test material (as cited in study report): N,N-dimethylacrylamide
- Physical state: clear, water-like liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River
- Weight at study initiation: 142-246 g (males), 167-230 g (females)
- Fasting period before study: overnight prior to dosing
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: distilled water
- Doses:
- 46.4, 100.0, 215.0, 464.0 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: at one, four and 24 hours, and once daily thereafter
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- Mortality data was analysed statistically by the method of Litchfield, J. T., and Wilcoxon, F., J. Pharmacol. Exptl. Therap. 96, 99, 1949.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 215 - < 464 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals of the high dose group (464 mg/kg bw) were found dead 24 hours after dosing.
No deaths occurred in the other dose groups. - Clinical signs:
- other: 46.4, 100 and 215 mg/kg bw: All animals appeared slightly depressed at four hours. After 24 hours, all animals appeared normal. 464 mg/kg bw: Slight depression was observed in all animals immediately postdose. Hunching, depression, and ataxia or ptosis at
- Gross pathology:
- No observable gross pathology was noted at death or termination.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
