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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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Diss Factsheets
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EC number: 416-600-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Additional information
HAT-ISO was tested for aquatic toxicity in a number of tests including EU-Method C.1, Acute toxicity to fish, EU-Method C.2, Acute toxicity to Daphnia and EU-Method C.3, Acute toxicity to algae. Following results were obtained:
Acute toxicity to fish in the test with Brachydanio rerio revealed a 96 h LD50 of > 250 mg/L (nominal concentration). The 96 h-NOEC in the fish toxicity test was > 250 mg/L (nominal concentration).
Acute toxicity to aquatic invertebrates in the test with Daphnia magna revealed a 48 h EC50 of > 100 mg/L (nominal concentration). The 48 h-NOEC in the Daphnia toxicity test was > 100 mg/L (nominal concentration).
Acute toxicity to freshwater green algae was investigated in two studies. In the key study, toxicity to aquatic algae Desmodesmus subspicatus revealed a 72 h EC50 (growth rate) of > 100 mg/L (nominal concentration). The 72 h-NOEC in the algae inhibition test was > 100 mg/L (nominal concentration). In the supporting study, the 72 h EC50 (growth rate) to Desmodesmus subspicatus was determined to be ca. 76 mg/L (nominal concentration), with a 95 % confidence interval of 54 to 108 mg/L. This value was regarded as invalid, as post testing analysis of the test material revealed that the batch used for testing was contaminated with solvent residues.
The toxicity of HAT-ISO to microorganisms was tested in a 3 h activated sludge respiration inhibition test. The 3 h EC 50 was determined to be > 100 mg/L (nominal concentration). HAT-ISO was considered non-toxic to aquatic microorganisms.
In summary, none of the aquatic toxicity studies revealed toxicity of the test material HAT-ISO. Further testing of HAT-ISO, e.g. in long-term toxicity tests, was considered not scientifically justified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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