Registration Dossier
Registration Dossier
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EC number: 213-424-8 | CAS number: 947-04-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
see "Additional information"
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Renal excretion of lauryl lactam could be demonstrated in a follow up study of the 90 day oral repeated dose toxicity study (SANOFI, 1993). Urine samples (5 ml/animal) were collected from 5 animals/sex/group on days 45 and 85 from the rats 90 day oral repeated dose toxicity study (Arkema, 2009) and quantification of lauryl lactam via gas chromatography-flame ionization detector was performed in urine samples on 5 males and 4 females of the highest dose group (125 mg/kg/day; Arkema, 2009). Lauryl lactam could be detected in these examined urine samples. There is no further information available on toxicokinetics, metabolism or distribution of lauryl lactam.
The structurally related compound ε-caprolactam was examined regarding toxicokinetics in male, female and pregnant female mice (Waddell et al., 1984).
After oral or i.v. administration of
radioactive labelled ε-caprolactam
the substance was rapidly absorbed and distributed throughout the
animals including the foetuses. There was no retention of radioactivity
observed in foetuses.
No differences in pattern of distribution among male, non-pregnant and
pregnant mice could be detected. The substance ε-caprolactam
is rapidly eliminated by renal and hepatic routes. Metabolism in liver
prior to secretion into bile seems likely.There are indications that
enterohepatic circulation is absent. Because of structural similarities
between ε-caprolactam
and lauryl lactam it is assumed that lauryl lactam shows similar
toxicokinetic behaviour.
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