Menthol

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Principles of method if other than guideline:

no data

GLP compliance:

not specified

Type of method:

other: no data

Key result

Water solubility:

456 mg/L

Temp.:

25 °C

Remarks on result:

other: pH is not reported

Conclusions:

Interpretation of results: moderately soluble (100-1000 mg/L)
The water solubility of Menthol is 456 mg/l at 25°C.

Executive summary:

The water solubility of DL-Menthol is 456 mg/l at 25°C.

Reference 2

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Principles of method if other than guideline:

The test was performed according to EU Method A. 6 (Water Solubility). The methods described are based on the OECD Test Guideline.

GLP compliance:

yes

Type of method:

flask method

Water solubility:

508 mg/L

Temp.:

20 °C

pH:

6.3

Details on results:

In a preliminary test, the water solubility of Menthol was determined to be > 0.01 g/l. Therefore, the flask method was chosen for the determination of the water solubility.

Water solubility of Menthol at 20°C:

Flask	Determination	test conc.(mg/l)	pH-value	test solution (ml)
1	I	538.9	6.3	25
	II	527.3		25
2	I	483.7	6.3	25
	II	488.6		25
3	I	518.6	6.3	25
	II	492.5		25
Average		508

Conclusions:

Interpretation of results: moderately soluble (100-1000 mg/L)

Executive summary:

The water solubility of DL-Menthol (CAS no. 1490 -04 -6) was determined using the method OECD Guideline 105 and EC Guideline A.6. Menthol is moderately soluble: 508 mg/L at 20 °C and pH 6.3 (Bayer AG, 1989).

Reference 3

Endpoint:

water solubility

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

accepted calculation method

Principles of method if other than guideline:

A Computer program has been developed for estimating both the partition coefficient between 1-octanol and water phases and the aqueous solubility from the structural formula. This system is an extended version of a previously described program entitled CHEMICALC for the automatic estimation of the partition coeficient. The aqueous solubility is estimated via two pathways. The first is based on the estimation from logPow. In the second, combined handling of two available group contribution methods.

Type of method:

other: estimating

Water solubility:

402 mg/L

Temp.:

43 °C

Remarks on result:

other: pH not reported

Conclusions:

Interpretation of results: moderately soluble (100-1000 mg/L)

Executive summary:

The water solubility of Menthol has been estimated as 402 mg/L at 43 °C.

Reference 4

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Principles of method if other than guideline:

A stalogmometric method was used, according to which the number of drops per unit of time in the case of saturated solutions and their dilutions were compared with similar determinations upon a series of solutions of known content. For obtaining saturation lon periods of shaking were often necessary.

GLP compliance:

not specified

Type of method:

other: Stalogmometric method

Water solubility:

420 mg/L

Temp.:

20 °C

Remarks on result:

other: pH not reported

Conclusions:

Interpretation of results: moderately soluble (100-1000 mg/L)

Executive summary:

The author used a stalogmometric method, in which the number of drops per unit of time in the case of saturated solutions and their dilutions were compared with similar determinations upon a series of solutions of known content. For obtaining saturation long period of shaking were often necessary.

The water solubility of Menthol was determined as 420 mg/L at 20 °C.

Description of key information

The water solubility of DL-Menthol is determined as 456 mg/l at 25 °C (Yalkowsky 2010) and has been estimated as 402 mg/L at 43 °C (Suzuki 1991).

For Menthol the water solubility has been determined as 508 mg/L at 20 °C and pH 6.3 (Bayer AG, 1989) and as 420 mg/L at 20 °C (Seidell 1941).

Key value for chemical safety assessment

Water solubility:

456 mg/L

at the temperature of:

25 °C