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Diss Factsheets
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EC number: 201-939-0 | CAS number: 89-78-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990-03-19 till 1990-04-17
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: UBA-Verfahrensvorschlag: "Letale Wirkung beim Zebrabaerbling Brachydanio rerio, LC0, LC50, LC100; 48-96 h" (Mai 1984)
- Version / remarks:
- Guideline proposal of the German Federal Environmental Agency (UBA)
- GLP compliance:
- yes
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 131136 - Analytical monitoring:
- yes
- Details on sampling:
- direct weighted
- Vehicle:
- no
- Details on test solutions:
- test medium (synthetic origin, prepared according to ISO)
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- - origin: West-Aquarium (Bad Lauterberg, Germany)
- ventilated test system
- loading rate: 10 animals/vessel (3 month old)
- Length: 2.5 to 3.5 cm - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- 22.3°C
- pH:
- 7.6
- Dissolved oxygen:
- 8.5 mg/L
99.6 % - Nominal and measured concentrations:
- Nominal: 7.8, 11, 16, 22 and 31 mg/L
Measured (in mean): 6.4, 9.3, 11.3, 18.7 and 26.2 mg/L - Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 16 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 22.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 31 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- The fish were exposed to 5 nominal test substance concentrations in the range of 7.8 to 31 mg/L. In all test media, undissolved substance particles
remained on the water surface. Analytical measurements revealed that the test substance concentrations decreased below 80 % of the nominal within 96 h, probably due to volatilization. - Validity criteria fulfilled:
- yes
- Remarks:
- - dissolved oxygen concentration remained above 60% of the air-saturation value throughout the exposure period. - No mortality in the controls by the end of the test.
- Conclusions:
- In a study with fish (Danio rerio) a LC50 of 22.3 mg/L (geom. mean from nominal concentration) after 96 hours is obtained.
- Executive summary:
The study was conducted according to Umweltbundesamt (UBA) -Verfahrensvorschlag: "Letale Wirkung beim Zebrabaerbling Brachydanio rerio, Mai 1984" with fish (Danio rerio). The fish were exposed to 5 nominal concentrations of DL-Menthol in the range of 7.8 to 31 mg/L ( 7.8, 11, 16, 22 and 31 mg/L). 10 fish were tested per concentration level. A LC50 of 22.3 mg/L (geom. mean from nominal concentration) after 96 hours is obtained.
Reference
Description of key information
The study was conducted according to Umweltbundesamt (UBA) -Verfahrensvorschlag: "Letale Wirkung beim Zebrabaerbling Brachydanio rerio, Mai 1984" with fish (Danio rerio). The fishs were exposed to 5 nominal concentrations of DL-Menthol in the range of 7.8 to 31 mg/L ( 7.8, 11, 16, 22 and 31 mg/L). 10 fish were tested per concentration level. A LC50 of 22.3 mg/L (geom. mean from nominal concentration) after 96 hours is obtained.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 22.3 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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