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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to other above-ground organisms

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toxicity to other above-ground organisms
Type of information:
experimental study
Adequacy of study:
key study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
no guideline followed
Principles of method if other than guideline:
Dietary toxicity study in dogs
GLP compliance:
not specified
Test organisms (species):
other: Canis familiaris
Details on test organisms:
female beagle dogs, 7 to 8 months old
Study type:
laboratory study
Total exposure duration:
183 d
Nominal and measured concentrations:
0.58, 1.15, 2.31 mg As/ kg diet
Key result
183 d
Dose descriptor:
other: NOEL
Effect conc.:
1.04 other: mg/kg bw/d
Nominal / measured:
not specified
Conc. based on:
Basis for effect:
other: growth, feed consumption
This study shows that dietary sodium arsenite causes a dose-dependent decrease of feed consumption and body weight in female dogs. A NOAEL of 1.04 mg As/kg bw/d was observed (based on a test concentration of 1.15 mg As/kg diet). Applying a conversion factorr of 40 (g bw/g diet per day), this NOAEL corresponds to a NOEC of 41.6 mg As/kg diet.

Description of key information

The lowest NOAEL for mammals (1.04 mg As/kg diet) was observed in a 183-days study with female beagle dogs exposed to exposed to arsenic via food (Neiger and Osweiler, 1989). Applying a conversion factor of 40 (g bw/g diet per day), this NOAEL corresponds to a NOEC of 41.6 mg As/kg diet.

Key value for chemical safety assessment

Long-term EC10, LC10 or NOEC for mammals:
41.6 mg/kg food

Additional information

Only few water accommodated fraction (WAF) based acute aquatic ecotoxicity data are available for the poorly soluble substance gallium arsenide (GaAs). For metals and poorly soluble metal compounds, WAF testing should not be used and ecotoxicity information should be derived with tests on a soluble metal salt and differences in solubility addressed by results from transformation/dissolution tests on the poorly soluble compound. Upon dissolution, GaAs yields both soluble gallium and arsenic ions. Because the available toxicity data show that As ions are more toxic in the environment compared to Ga ions, the ecotoxicity of GaAs is predicted based on read across from GaAs to soluble inorganic As compounds. In order to still account for the potential contribution of Ga ions to toxicity of GaAs in the environment, the toxicity results for As ions are not corrected for their abundance in GaAs, which means that the toxicity of Ga is considered similar as As. This is a worst-case scenario based on the available toxicity data for soluble Ga and As compounds.