Gallium arsenide

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Brief report, however giving sufficient experimental detail. Similar to guideline test methods.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

1984

Report date:

1983

Materials and methods

Principles of method if other than guideline:

No guideline available at the time. Conduct similar to subsequently developed guidelines.

GLP compliance:

no

Test type:

other: limit test

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Galliumarsenid - Probably a mechanically destroyed material not marketed.

IUPAC Name:

Galliumarsenid - Probably a mechanically destroyed material not marketed.

Details on test material:

- Name of test material (as cited in study report): Galliumarsenid
no details available

Test animals

Species:

rat

Strain:

Wistar

Sex:

female

Details on test animals or test system and environmental conditions:

Normal food and drinking water ad libitum. Room temperature 20°-24°, relative humidity 40-65%. Animal age at start of test 8-10 weeks. Average body weight 185.5 +- 18g.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: suspended in traganth solution (1%)

Details on oral exposure:

Animals were fasted 16 h before oral dosing.

Doses:

From the report it appears that several doses were tested. However, only the limit dose of 10000 mg/kg bw is actually stated.

No. of animals per sex per dose:

Not stated

Control animals:

not specified

Details on study design:

Observation period 14 days.

Statistics:

not available

Results and discussion

Effect levels

Sex:

female

Dose descriptor:

LD0

Effect level:

> 10 000 mg/kg bw

Based on:

test mat.

Mortality:

no mortality observed

Clinical signs:

other: general behaviour appeared unaffected

Gross pathology:

no substance related changes in organs observed

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: EU

Executive summary:

A single oral dosage of 10000 mg GaAs/kg bw was administered to female Wistar rats. The test article was suspended in 1% traganth solution. The rats were kept at room temperature 20°-24°, a relative humidity of 40-65% and with free access to food and water. Animal age at start of test was 8-10 weeks and the average body weight 185.5 +- 18g. The observation period after administration was 14 days. No substance related changes were observed with the animals. Study design similar to guideline test method.

LD50 rat, female, oral > 10000mg GaAs/kg bw.