Registration Dossier
Registration Dossier
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EC number: 201-224-3 | CAS number: 79-77-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Data from secondary source which meets basic scientific principles. Due to structural similarities of the registered substance trans-ß-ionone (CAS 79-77-6) and the used test substance ß-ionone (CAS 14901-07-6) the study data could be taken into account for assessment.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Short term toxicity study on alpha-ionone, beta-ionone and citral
- Author:
- Givaudan
- Year:
- 1 980
- Bibliographic source:
- cited in the RIFM/FEMA database, location 43485
- Report date:
- 1980
- Reference Type:
- secondary source
- Title:
- Fragrance material review on alpha-ionone
- Author:
- Lalko J et al.
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology 45 (2007) S235–S240
- Reference Type:
- secondary source
- Title:
- A toxicologic and dermatologic assessment of ionones when used as fragrance ingredients
- Author:
- Belsito D et al.
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology 45 (2007) S130–S167
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Administration: daily, 5 times
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-(2,6,6-trimethylcyclohex-1-ene-1-yl)-but-3-ene-2-one
- EC Number:
- 238-969-9
- EC Name:
- 4-(2,6,6-trimethylcyclohex-1-ene-1-yl)-but-3-ene-2-one
- Cas Number:
- 14901-07-6
- IUPAC Name:
- 4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-3-en-2-one
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- - Administration: daily, 5 times
- Doses:
- no data
- No. of animals per sex per dose:
- 10 animals/dose
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 7 120 mg/kg bw
- Remarks on result:
- other: +/- 1000 mg/kg bw for deaths occuring within 24 h
- Sex:
- not specified
- Dose descriptor:
- other: LD10
- Effect level:
- 4 120 mg/kg bw
- Remarks on result:
- other: for deaths occuring within 24 h
- Sex:
- not specified
- Dose descriptor:
- other: LD90
- Effect level:
- 12 300 mg/kg bw
- Remarks on result:
- other: for deaths occuring within 24 h
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 290 mg/kg bw
- Remarks on result:
- other: +/- 500 mg/kg bw for deaths occuring within 10 days
- Sex:
- not specified
- Dose descriptor:
- other: LD10
- Effect level:
- 2 150 mg/kg bw
- Remarks on result:
- other: for deaths occuring within 10 days
- Sex:
- not specified
- Dose descriptor:
- other: LD90
- Effect level:
- 5 040 mg/kg bw
- Remarks on result:
- other: for deaths occuring within 10 days
- Mortality:
- All deaths had occurred by 24 hours
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
