Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient data documentation.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1958

Materials and methods

Type of study / information:
in vivo irritation study in human.
Endpoint addressed:
skin irritation / corrosion
Principles of method if other than guideline:
skin irritation study in human
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Tris(2-ethylhexyl) phosphate
EC Number:
201-116-6
EC Name:
Tris(2-ethylhexyl) phosphate
Cas Number:
78-42-2
Molecular formula:
C24H51O4P
IUPAC Name:
tris(2-ethylhexyl) phosphate
Details on test material:
no data

Method

Details on study design:
no data
Exposure assessment:
not specified

Results and discussion

Results:
No irritant effects were seen after 24 h of exposure to a test substance-saturated cotton swab placed on the skin of the forearm of six volunteers. A piece (2 cm²) of PVC plastic containing 40% of test substance was placed on the arm of 8 volunteers for 72 h. Slight redness but no irritation was observed.

Any other information on results incl. tables

No irritant effects were seen after 24 h of exposure to a test substance-saturated cotton swab placed on the skin of the forearm of six volunteers. A piece (2 cm²) of PVC plastic containing 40% of test substance was placed on the arm of 8 volunteers for 72 h. Slight redness but no irritation was observed.

Applicant's summary and conclusion

Executive summary:

No irritant effects were seen after 24 h of exposure to a test substance-saturated cotton swab placed on the skin of the forearm of six volunteers. A piece (2 cm²) of PVC plastic containing 40% of test substance was placed on the arm of 8 volunteers for 72 h. Slight redness but no irritation was observed.