Registration Dossier
Registration Dossier
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EC number: 201-280-9 | CAS number: 80-46-6
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Davoren and Fogarty (2005) conducted a reliable study with the ciliated protozoan, Tetrahymena thermophilia where the 24hr EC50, based on inhibition was 4.5 mg/L and NOEC was 1.8 mg/L
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 1.8 mg/L
Additional information
Reliable (Klimisch 1 or 2) short-term toxicity studies with microorganisms have been conducted for p-tert-amylphenol and are included in this dossier.
Davoren and Fogarty (2005) conducted a reliable (Klimisch 2) study according to procedures presented by the Protoxkit F with sodium p-tert-amylphenol with a protozoan species. Data obtained from tests using the salt is assumed to be representative of the parent substance due to its weak acid properties. The ciliated protozoan, Tetrahymena thermophilia was exposed to nominal concentrations (1.0-10 mg/L) of the test substance for 24 hours. The 24-hr EC50 and NOEC for Tetrahymena thermophilia, based on inhibition, are 4.5 and 1.8 mg/L, respectively.
The toxicity of sodium p-tert-amylphenol exposed to a marine bacterium was investigated by Davoren and Fogarty (2005) (Klimisch 2). Data obtained from tests using the salt is assumed to be representative of the parent substance due to its weak acid properties. The marine bacterium,Vibrio fischeri, was exposed to the test chemical for 15 minutes following British Standard Guidelines. The 15 min EC50, based on inhibition, was 0.8 mg/L.
Schultz (1987) conducted a reliable (Klimisch 2) study where the ciliated protozpan, Tetrahymena pyriformis, was exposed to concentrations of p-tert-amylphenol for 48 hours. The 48-hr EC50 is 9.6 mg/L.
Adequate reliable measured data exists for toxicity to microorganisms to p-tert-amylphenol and has been documented within this dossier. The data point of highest concern for this endpoint has been identified in a reliable study which reports the 24 hr NOEC of 1.8 mg/L. Consequently this value will be taken as the toxicity microorganisms endpoint for p-tert-amylphenol.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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