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Diss Factsheets
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EC number: 200-902-6 | CAS number: 75-79-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The rat acute oral LD50 values were reported to be <0.25 ml/kg and <1 ml/kg for males and females, repectively in a key study for undiluted test material (BRRC 1981), equivalent to ca. <320 mg/kg bw in males. The key acute inhalation study (DCC 1997) reported a 1 hour LC50 value of 1365ppm (equivalent to 8.3 mg/l) and the acute dermal LD50 was 1804 mg/kg in males and 1076 mg/kg in females (BRRC 1981). The necropsy findings of the decedents identified distended and fluid filled stomachs and discoloured internal organs. All the key studies were well reported and conducted according to a test protocol that is comparable to the EU test method.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 320 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 8 345 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 1 076 mg/kg bw
Additional information
The most recent and reliable studies were selected as key. Regarding the LD/LC50s for acute oral and inhalation, the results from supporting studies are consistent with the key studies in that they trigger a proposal for classification. No supporting studies are available for the dermal endpoint.
Since trichloro(methyl)silane is rapidly hydrolysed to methylsilanetriol and hydrogen chloride in the presence of moisture, adverse effects observed following acute exposure by all routes will be dominated by local corrosive effects, and other apparently adverse systemic effects could possibly be secondary to these local effects.
Justification for classification or non-classification
On the basis of the available data, the test substance is labelled 'R20/21/22 Harmful by inhalation, in contact with skin and if swallowed', under Directive 67/548/EEC. There is currently no classification for acute toxicity endpoints in Annex I of 67/548/EEC.
Based on an oral LD50of less than 320 mg/kg bw it is proposed that trichloro(methyl)silane be classified as Acute Toxic 4 (oral) under Regulation 1272/2008. Similarly, for the dermal route it is proposed that trichloro(methyl)silane be classified as Acute Toxic 4 (dermal), based on the LD50in females of 1076 mg/kg bw and 1804 mg/kg bw in males. An LC50of 8.4 mg/l (1 -hour) leads to the proposal that trichloro(methyl)silane be classified as Acute Toxic 3 (vapour) for the inhalation route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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