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Diss Factsheets
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EC number: 200-902-6 | CAS number: 75-79-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to a test protocol that is comparable to the appropriate OECD test guideline. It was not compliant with GLP and an occlusive dressing was used.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: DOT Corrosivity test
- GLP compliance:
- not specified
- Remarks:
- Although a GLP statement was not included with the report, it is known that Bushy Run Research Center (BRRC) operated as a GLP-facility at the time the testing was conducted.
Test material
- Reference substance name:
- Trichloro(methyl)silane
- EC Number:
- 200-902-6
- EC Name:
- Trichloro(methyl)silane
- Cas Number:
- 75-79-6
- Molecular formula:
- CH3Cl3Si
- IUPAC Name:
- trichloro(methyl)silane
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- One male and one female were used.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- undiluted; 0.5 mL
- Duration of treatment / exposure:
- 3 minute(s)
- Observation period:
- 2 days
- Number of animals:
- 2
- Details on study design:
- 0.5 mL (undiluted) was applied to the clipped, intact skin under a gauze patch and was loosely covered with impervious sheeting. The animals were restrained for the 3-min contact period. Excess sample was removed after contact. Skin reaction was scored by the method of Draize at one hour and at 1 and 2 days after dosing.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: overall result
- Basis:
- mean
- Time point:
- other: 1 hour
- Reversibility:
- not reversible
- Remarks on result:
- other: Full thickness necrosis in both test animals
- Irritant / corrosive response data:
- A 3-minute application of 0.5 ml of the test material undiluted to occluded rabbit skin resulted in moderate edema and full thickness necrosis on 2 of 2 rabbits within one hour after contact. Erythema was not visible around the necrosed site. Ulceration was observed on both animals at 24 hours with the tissue of the dose site of one animal apparently completely destroyed. This animal was euthanized for humane reasons. The remaining animal had severe ulceration (tissue destruction) at 48 hours and was euthanized after examination.
Any other information on results incl. tables
Table 1: Irritant/corrosive response data for each animal at each observation time up to removal of each animal from the test
Score at time point / Reversibility |
Erythema |
Edema |
Max. score: 4 |
Max. score: 2 |
|
60 min |
0/0 |
2/2 |
24 h |
U/0 |
U/2 |
48 h |
-/0 |
-/3 |
*) Reversibility: c. = completely reversible;n.c. = not completely reversible; n. = not reversible. U= Scoring impossible because of severe ulceration.
Chemical fuming upon contact; moderate edema, full thickness necrosis, severe ulceration (tissue destruction) on 2 of 2 rabbits. The application of test material to rabbit skin resulted in severe irritation, including full thickness necrosis and complete ulceration. Erythema was not visible around the necrosed site. Ulceration was observed on both animals at 24 hours with the tissue of the dose site of one animal apparently completely destroyed. This animal was sacrificed for humane reasons at this time. The remianing animal had sevsere ulceration (tissue destruction) at 48 hours and was sacrificed after examination.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material was determined to be corrosive in a reliable study conducted according to an appropriate test protocol. Not conducted according to GLP. On the basis of the severe effects observed, a proposal for classification as (Corrosive; Skin Corr 1A) is made, which is more stringent than the existing official EU classification.
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