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EC number: 215-535-7 | CAS number: 1330-20-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://poisoncentres.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non- GLP, guideline study, published in peer reviewed literature, acceptable with restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- Modified as adequate for testing volatile compounds.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material:
Not applicable - Analytical monitoring:
- yes
- Details on sampling:
- The concentration of the toxicant was determined at the beginning and end of the experiment.
- Vehicle:
- no
- Details on test solutions:
- Diluted solutions of aromatics were prepared from saturated aqueous solutions.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Data not reported
- Test type:
- other: Closed, static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Post exposure observation period:
- None
- Hardness:
- Data not reported
- Test temperature:
- Data not reported
- pH:
- Data not reported
- Dissolved oxygen:
- Data not reported
- Salinity:
- Not applicable
- Conductivity:
- N/A
- Nominal and measured concentrations:
- Nominal and measured concentrations not stated. Authors state that mean measured concentrations fluctuated within 10%.
- Details on test conditions:
- The determination of 24 h IC50 (immobilisation concentartion for 50% of the organisms) on Daphnia was performed in closed bottle (150mL), completely filled with the test solution.
- Reference substance (positive control):
- no
- Key result
- Duration:
- 24 h
- Dose descriptor:
- IC50
- Effect conc.:
- 2.2 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Results refer to mean measured concentrations, whose fluctuations were within 10%.
- Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- Data not reported
- Validity criteria fulfilled:
- not specified
- Remarks:
- insufficient data to confirm validity
- Conclusions:
- The reported IC50 for Daphnia magna was 2.2 mg/L.
- Executive summary:
The reported IC50 for Daphnia magna was 2.2 mg/L. This study has been conducted according to OECD standard guidelines, analytical monitoring was performed and appropriate modifications for volatile compounds were made. Raw data were not included and therefore the validity of the test can not be confirmed.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, guideline study, published in peer reviewed literature, acceptable with restrictions.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- Modified as adequate for testing volatile compounds.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material:
Not applicable - Analytical monitoring:
- yes
- Details on sampling:
- The concentration of the toxicant was determined at the beginning and end of the experiment.
- Vehicle:
- no
- Details on test solutions:
- Diluted solutions of aromatics were prepared from saturated aqueous solutions.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Data not reported
- Test type:
- other: Closed, static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Post exposure observation period:
- None
- Hardness:
- Data not reported
- Test temperature:
- Data not reported
- pH:
- Data not reported
- Dissolved oxygen:
- Data not reported
- Salinity:
- Not applicable
- Conductivity:
- N/A
- Nominal and measured concentrations:
- Nominal and measured concentrations not stated. Authors state that mean measured concentrations fluctuated within 10%.
- Details on test conditions:
- The determination of 24 hour IC50 (immobilisation concentartion for 50% of the organisms) on Daphnia was performed in closed bottle (150 mL), completely filled with the test solution.
- Reference substance (positive control):
- no
- Key result
- Duration:
- 24 h
- Dose descriptor:
- IC50
- Effect conc.:
- 4.7 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Results refer to mean measured concentrations, whose fluctuations were within 10%.
- Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- Data not reported
- Validity criteria fulfilled:
- not specified
- Remarks:
- insufficient data to confirm validity
- Conclusions:
- The reported IC50 for Daphnia magna was 4.7mg/L.
- Executive summary:
This has been chosen as the key study on the basis that it has been conducted according to OECD standard guidelines, analytical monitoring was performed and appropriate modifications for volatile compounds were made. Raw data was not included and therefore the validity of the test can not be confirmed.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2015
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- The Target Lipid Model (TLM) is a framework that relates toxicity to the physicochemical properties of a nonpolar organic constituent. It is a well documented and peer reviewed model that is widely used across the petrochemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions.
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- The endpoint calculated is the LL50, EL50, and NOELR -
The narcosis TLM was developed to predict the toxicity of chemicals to aquatic organisms that act via narcosis. It is based on the hypothesis that target lipid is the site of toxic action within the organism, that octanol is the appropriate surrogate, and that target lipid has the same physical–chemical properties in all organisms.
The approach describes:
• The theory and how to predict the acute toxicity to these organisms;
• Development of an Acute to Chronic ratio [ACR] for only hydrocarbons and for 29 data points.
The logkow used for calculation:
m- xylene= 3.20 - Specific details on test material used for the study:
- N/A
- Details on sampling:
- N/A
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- N/A
- Remarks on exposure duration:
- N/A
- Post exposure observation period:
- N/A
- Hardness:
- N/A
- Test temperature:
- N/A
- pH:
- N/A
- Dissolved oxygen:
- N/A
- Salinity:
- N/A
- Conductivity:
- N/A
- Nominal and measured concentrations:
- N/A
- Details on test conditions:
- N/A
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LL50
- Effect conc.:
- 8.73 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other:
- Details on results:
- N/A
- Results with reference substance (positive control):
- N/A
- Reported statistics and error estimates:
- N/A
- Conclusions:
- The estimated LL50 of Oncorhynchus mykiss for this substance is 8.730 mg/L. The target substance is a hydrocarbon acting via baseline toxicity, and falls within the parametric, structural and mechanistic domain of the model.
- Executive summary:
The short-term aquatic toxicity to this substance was estimated using the Target Lipid Model based on methologies described by McGrath et al. (2004, 2015). The estimated LL50 of Oncorhynchus mykiss for this substance is 8.730 mg/L.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, guideline study, published in peer reviewed literature, acceptable with restrictions.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- appropriate modifications for volatile compounds
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material:
Not applicable - Analytical monitoring:
- yes
- Details on sampling:
- The concentration of the toxicant was determined at the beginning and end of the experiment.
- Vehicle:
- no
- Details on test solutions:
- Data not reported
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Data not reported
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Post exposure observation period:
- None
- Hardness:
- Data not reported
- Test temperature:
- Data not reported
- pH:
- Data not reported
- Dissolved oxygen:
- Data not reported
- Salinity:
- Not applicable
- Conductivity:
- N/A
- Nominal and measured concentrations:
- Nominal and measured concentrations not stated. Authors state that mean measured concentrations fluctuated within 10%.
- Details on test conditions:
- The determination of 24 hour IC50 (immobilisation concentartion for 50% of the organisms) on Daphnia was performed in closed bottle (150 mL), completely filled with the test solution.
- Reference substance (positive control):
- no
- Key result
- Duration:
- 24 h
- Dose descriptor:
- IC50
- Effect conc.:
- 1 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: results refer to mean measured concentrations, whose fluctuations were within 10%.
- Details on results:
- Data not reported
- Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- Data not reported
- Validity criteria fulfilled:
- not specified
- Remarks:
- Insufficient data to confirm validity
- Conclusions:
- The reported IC50 for Daphnia magna for o-xylene was 1 mg/L.
- Executive summary:
This has been chosen as the key study on the basis that it has been conducted according to OECD standard guidelines, analytrical monitoring was performed and appropriate modifications for volatile compounds were made. Raw data was not included and therefore the validity of the test can not be confirmed.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2015
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- The Target Lipid Model (TLM) is a framework that relates toxicity to the physicochemical properties of a nonpolar organic constituent. It is a well documented and peer reviewed model that is widely used across the petrochemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions.
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- The endpoint calculated is the LL50, EL50, and NOELR -
The narcosis TLM was developed to predict the toxicity of chemicals to aquatic organisms that act via narcosis. It is based on the hypothesis that target lipid is the site of toxic action within the organism, that octanol is the appropriate surrogate, and that target lipid has the same physical–chemical properties in all organisms.
The approach describes:
• The theory and how to predict the acute toxicity to these organisms;
• Development of an Acute to Chronic ratio [ACR] for only hydrocarbons and for 29 data points.
The logkow used for calculation:
o-xylene= 3.12 - Specific details on test material used for the study:
- N/A
- Details on sampling:
- N/A
- Details on test solutions:
- N/A
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- N/A
- Post exposure observation period:
- N/A
- Hardness:
- N/A
- Test temperature:
- N/A
- pH:
- N/A
- Dissolved oxygen:
- N/A
- Salinity:
- N/A
- Conductivity:
- N/A
- Nominal and measured concentrations:
- N/A
- Details on test conditions:
- N/A
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 10.389 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other:
- Details on results:
- N/A
- Results with reference substance (positive control):
- N/A
- Reported statistics and error estimates:
- N/A
- Conclusions:
- The estimated LC50 of Oncorhynchus mykiss for this substance is 10.389 mg/L. The target substance is a hydrocarbon acting via baseline toxicity, and falls within the parametric, structural and mechanistic domain of the model.
- Executive summary:
The short-term aquatic toxicity to this substance was estimated using the Target Lipid Model based on methologies described by McGrath et al. (2004, 2015). The estimated LC50 of Oncorhynchus mykiss for this substance is 10.389 mg/L.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, guideline study, published in peer reviewed literature, acceptable with restrictions.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- yes
- Remarks:
- Modified as adequate for testing volatile compounds.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material:
Not applicable - Analytical monitoring:
- yes
- Details on sampling:
- The concentration of the toxicant was determined at the beginning and end of the experiment.
- Vehicle:
- no
- Details on test solutions:
- Diluted solutions of aromatics were prepared from saturated aqueous solutions.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Data not reported
- Test type:
- other: Closed, static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Post exposure observation period:
- None
- Hardness:
- Data not reported
- Test temperature:
- Data not reported
- pH:
- Data not reported
- Dissolved oxygen:
- Data not reported
- Salinity:
- Not applicable
- Conductivity:
- N/A
- Nominal and measured concentrations:
- Nominal and measured concentrations not stated. Authors state that mean measured concentrations fluctuated within 10%.
- Details on test conditions:
- The determination of 24 hour IC50 (immobilisation concentartion for 50% of the organisms) on Daphnia was performed in closed bottle (150 mL), completely filled with the test solution.
- Reference substance (positive control):
- no
- Key result
- Duration:
- 24 h
- Dose descriptor:
- IC50
- Effect conc.:
- 3.6 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Results refer to mean measured concentrations, whose fluctuations were within 10%.
- Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- Data not reported
- Validity criteria fulfilled:
- not specified
- Remarks:
- insufficient data to confirm validity
- Conclusions:
- The reported 24 hour IC50 for Daphnia magna for p-xylene was 3.6 mg/L.
- Executive summary:
This has been chosen as the key study on the basis that it has been conducted according to OECD standard guidelines, analytrical monitoring was performed and appropriate modifications for volatile compounds were made. Raw data was not included and therefore the validity of the test can not be confirmed.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2015
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- The Target Lipid Model (TLM) is a framework that relates toxicity to the physicochemical properties of a nonpolar organic constituent. It is a well documented and peer reviewed model that is widely used across the petrochemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions.
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- The endpoint calculated is the LL50, EL50, and NOELR -
The narcosis TLM was developed to predict the toxicity of chemicals to aquatic organisms that act via narcosis. It is based on the hypothesis that target lipid is the site of toxic action within the organism, that octanol is the appropriate surrogate, and that target lipid has the same physical–chemical properties in all organisms.
The approach describes:
• The theory and how to predict the acute toxicity to these organisms;
• Development of an Acute to Chronic ratio [ACR] for only hydrocarbons and for 29 data points.
The logkow used for calculation:
p-xylene= 3.09 - Specific details on test material used for the study:
- N/A
- Details on sampling:
- N/A
- Details on test solutions:
- N/A
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- N/A
- Post exposure observation period:
- N/A
- Hardness:
- N/A
- Test temperature:
- N/A
- pH:
- N/A
- Dissolved oxygen:
- N/A
- Salinity:
- N/A
- Conductivity:
- N/A
- Nominal and measured concentrations:
- N/A
- Details on test conditions:
- N/A
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LL50
- Effect conc.:
- 11.076 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other:
- Details on results:
- N/A
- Results with reference substance (positive control):
- N/A
- Reported statistics and error estimates:
- N/A
- Conclusions:
- The estimated LL50 of Oncorhynchus mykiss for for this substance is 11.076 mg/L.The target substance is a hydrocarbon acting via baseline toxicity, and falls within the parametric, structural and mechanistic domain of the model.
- Executive summary:
The short-term aquatic toxicity to this substance was estimated using the Target Lipid Model based on methologies described by McGrath et al. (2004, 2015). The estimated LL50 of Oncorhynchus mykiss for this substance is 11.076 mg/L.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2015
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- The Target Lipid Model (TLM) is a framework that relates toxicity to the physicochemical properties of a nonpolar organic constituent. It is a well documented and peer reviewed model that is widely used across the petrochemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions.
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- The endpoint calculated is the LL50, EL50, and NOELR -
The narcosis TLM was developed to predict the toxicity of chemicals to aquatic organisms that act via narcosis. It is based on the hypothesis that target lipid is the site of toxic action within the organism, that octanol is the appropriate surrogate, and that target lipid has the same physical–chemical properties in all organisms.
The approach describes:
• The theory and how to predict the acute toxicity to these organisms;
• Development of an Acute to Chronic ratio [ACR] for only hydrocarbons and for 29 data points.
The logkow used for calculation:
xylene = 3.16 - Specific details on test material used for the study:
- N/A
- Details on sampling:
- N/A
- Details on test solutions:
- N/A
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- N/A
- Post exposure observation period:
- N/A
- Hardness:
- N/A
- Test temperature:
- N/A
- pH:
- N/A
- Dissolved oxygen:
- N/A
- Salinity:
- N/A
- Conductivity:
- N/A
- Nominal and measured concentrations:
- N/A
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LL50
- Effect conc.:
- 9.519 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other:
- Details on results:
- N/A
- Results with reference substance (positive control):
- N/A
- Reported statistics and error estimates:
- N/A
- Conclusions:
- The estimated LL50 of Oncorhynchus mykiss for this substance is 9.519 mg/L. The target substance is a hydrocarbon acting via baseline toxicity, and falls within the parametric, structural and mechanistic domain of the model.
- Executive summary:
The short-term aquatic toxicity to this substance was estimated using the Target Lipid Model based on methologies described by McGrath et al. (2004, 2015). The estimated LL50 of Oncorhynchus mykiss for this substance is 9.519 mg/L.
Referenceopen allclose all
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
Description of key information
The lowest result is a 24 hour EC50 of 1 mg/L for o-xylene (Galassi 1988). The estimated LL50 values from TLM QSAR were 8.730 - 11.076 mg/L.
The experimental value was used for chemical safety assessment.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 1 mg/L
Additional information
Data are available on the acute toxicity of each of the xylene isomers and ethylbenzene to aquatic invertebrates. The study by Galassi et al (1988) follows OECD 202 and uses Daphnia magna, whilst Holcombe et al (1987) used a flow through system to expose different species (including Daphnia magna) simultaneously. Niederlehner et al (1998) used Ceriodaphnia dubia as the test organism. All studies included analytical confirmation of the exposure concentrations.
The 24 hour EC50 results reported in the key studies from Galassi at al (1988) for the xylene isomers and ethylbenzene are very similar, with a range of 1 - 4.7 mg/L. The lowest result will be used in the risk assessment.
A TLM modeling framework was used to support values derived experimentally and are presented as supporting studies.
The estimated LL50 values from TLM QSAR were 8.730 - 11.076 mg/L
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)