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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 215-535-7 | CAS number: 1330-20-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The lowest results for xylene isomers is a 28 day NOEC of 16 mg/L for o-xylene
The experimental NOEC was used for the chemical safety assessment.
The estimated EL50 values from TLM QSAR were 71.286 - 90.449 mg/L. The lowest EC50 from the TLM QSAR estimated values was used as EC50 for the chemical safety assessment.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 71.286 mg/L
- EC10 or NOEC for microorganisms:
- 16 mg/L
Additional information
Biodegradation tests were carried out on all three xylene isomers following OECD 301F guidelines using a mixed inoculum of non-adapted sludge and soil micro-organisms. In the toxicity control vessels, containing the individual xylene isomers with the reference substance sodium benzoate, none of the xylene isomers exhibited inhibitory effects on the micro-organisms. The 28 day NOEC (nominal concentration) is therefore 16 mg/L for m-xylene and 16.2 mg/L for o-xylene and p-xylene.
A TLM modeling framework was used to support values derived experimentally.
The TLM EC50 lowest value was used as key value for the chemical assessment due to a lack of information in the supporting experimental studies and because result to be more conservative compared to the lowest value from the supporting experimental study from Blum et al (1991).
The estimated EL50 values from TLM QSAR were 71.286 - 90.449 mg/L, The lowest EC50 from the TLM QSAR estimated values was used as EC50 value for the chemical safety assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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