Registration Dossier
Registration Dossier
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EC number: 203-466-5 | CAS number: 107-13-1
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
An anonymous author (Japan MoE, 2011) reports a 72-hour ErC50 of 10 mg/L (mean measured) for the inhibitory effects of acrylonitrile on the growth rate of the freshwater unicellular alga Pseudokirchneriella subcapitata. This study was performed on behalf of the Japanese Ministry of the Environment in accordance with a Japanese national method and OECD TG 201, and in compliance with GLP. The test was conducted under static conditions in OECD algal growth medium with sealed test vessels to limit volatilisation losses of the test substance and maintain exposure concentrations.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 10 mg/L
- EC10 or NOEC for freshwater algae:
- 0.95 mg/L
Additional information
The effects of acrylonitrile on the growth of P. subcapitata were reliably determined following exposure for 72 hours under static conditions in sealed vessels. Measured concentrations at test initiation (0 h) ranged between 91% and 99% of nominals and residual concentrations recovered at termination (72 h) were between 90% and 100% of nominals, demonstrating that exposure had been satisfactorily maintained during the incubation. All the guideline validity criteria were met. The 72-hour ErC50 was 10 mg/L and the corresponding NOErC was 0.95 mg/L. Since the NOErC relates to algal growth (cell multiplication), it is considered to be a long-term endpoint for the primary producer trophic group and is taken into account in setting the assessment factor for the derivation of the aquatic PNEC.
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