Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-466-5 | CAS number: 107-13-1
Toxicity to terrestrial arthropods
Administrative data
Link to relevant study record(s)
Description of key information
Reported LC50 values for various terrestrial arthrpod species were in the range 0.1 to 6.5 mg/l acrylonitrile.
Key value for chemical safety assessment
Additional information
The EU RAR reviews several studies conducted to assess the toxic effects of acrylonitrile when applied as a fumigant (in air) to various arthropod species known to infest food products.
The 8 hour LC50 for Sitophilus granarius, Tribolium confusum, Tenebrioides mauritanicus was 0.7 - 2.8 mg/l.
The 2 hour LC50 was 2 - 6.5 mg/l, and the 6 hour LC50 was 0.8 - 2.0 mg/l in Sitophilus oryza, Zabrotes pectoralis, Stegobium paniceum, Acanthoscelides obtectus, Oryzaephilus surinamensis and Rhyzopertha dominica.
The pupae of Callosobruchus chinensis were found to be more resistant to acrylonitrile than the eggs, larvae or adults, with a 24 hour LC50 of 1.26 mg/l compared to approximately 0.1 mg/l, respectively.
An LC50 of 0.8 - 1.1 mg/l was reported for adults and larvae of Tribolium castaneum and larvae of Trogoderma granarium. The LC50 concentrations of acrylonitrile significantly inhibited the enzymes trehalase and phosphorylase in both species. Sub-lethal concentrations had similar effects on Tribolium castaneum adults but had less effect on these enzymes at the larval stages in either soecies, and had no effect on acetylcholinesterase.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
