Prop-2-yn-1-ol

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1963

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study was performed prior to the implementation of GLP and OECD Guidelines, but is in general in compliance with the principles described in OECD Guideline 404.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1963

Report date:

1963

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Deviations:

not applicable

GLP compliance:

no

Remarks:

test predated GLP

Test material

Test material information

Constituent 1

Reference substance name:

Prop-2-yn-1-ol

EC Number:

203-471-2

EC Name:

Prop-2-yn-1-ol

Cas Number:

107-19-7

Molecular formula:

C3H4O

IUPAC Name:

prop-2-yn-1-ol

Details on test material:

No data

Test animals

Species:

rabbit

Strain:

Vienna White

Details on test animals or test system and environmental conditions:

no details given

Test system

Type of coverage:

occlusive

Preparation of test site:

not specified

Vehicle:

unchanged (no vehicle)

Controls:

no

Amount / concentration applied:

TEST MATERIAL
- Concentration (if solution): undiluted

Duration of treatment / exposure:

2 animals were treated for 1, 5 and 15 minutes and 2 other animals for 20 hours using occlusive conditions.

Observation period:

Animals survived were observed 8 days and skin changes were recorded on working days.

Number of animals:

8 animals were treated (2 animals per incubation group)

Details on study design:

An application site of 2.5 x 2.5 cm was covered with the liquid or powdered and moistened test substance.
In addition, skin tissue from the ear was tested by wrapping the ear in the group incubated for 20 h. These results from the ear, however, would not be taken into account for evaluation as they do not represent testing of the dorsal/lateral flank of the back.
After the application time, the skin was washed with water which sometimes contained a mild detergent.

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

edema score

Remarks:

(incubation period: 1 min)

Basis:

mean

Remarks:

of 2 animals

Time point:

other: 24 hours

Score:

1

Max. score:

4

Reversibility:

not fully reversible within: 8 days

Remarks on result:

other: superficial necrosis

Results 2

Irritation parameter:

edema score

Remarks:

(incubation period: 5 or 15 min)

Basis:

mean

Remarks:

of 2 animals

Time point:

other: 24 hours

Score:

1

Max. score:

4

Reversibility:

not fully reversible within: 8 days

Remarks on result:

other: full thickness necrosis

Irritant / corrosive response data:

5 or 15 minutes exposure: very slight edema and hemorrhages, severe necrosis and anemia after 8 days
20 hour exposure: skin irritation could not be evaluated because rabbits died after 4 hours of application

Applicant's summary and conclusion

Interpretation of results:

corrosive

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Propargyl alcohol exhibited a corrosive potential in the BASF key study.

Executive summary:

In a primary dermal irritation study Vienna White Rabbits were dermally exposed to undiluted Propargyl alcohol. Test sites (at the lateral/dorsal flank of the back) were covered with an occlusive dressing for 1, 5, 15 minutes or 20 hours. In case of rabbits with an incubation time of 20 hours, test substance was applied additionally to the skin of the ear.

In the 20 h incubation group, skin irritation could not be evaluated because all rabbits died after 4 hours of application. Rabbits of the other incubation groups survived and were observed for 8 days. Incubation for 1 min resulted in superficial necrosis. Incubation for 5 or 15 min caused necrosis through the epidermis and into the dermis (full thickness necrosis). Propargyl alcohol exhibited a corrosive potential in this study.