Registration Dossier
Registration Dossier
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EC number: 606-441-0 | CAS number: 201305-16-0
Endpoint summary
Administrative data
Description of key information
Additional information
One key study performed according to OECD 301B confirmed that Benzoic acid, 4-hydroxy-, C18-22-alkyl esters (CAS No. 201305-16-0) is not readily biodegradable according to OECD criteria. Therefore, persistence of this substance in the environment cannot be excluded. The degradation via abiotic hydrolysis is not considered to be a relevant degradation pathway in the environment since QSAR results using HYDROWIN v2.00 resulted in DT50 values > 1 yr at pH 7.
The adsorption potential ofBenzoic acid, 4-hydroxy-, C18-22-alkyl esters is high (log Koc > 5, KOCWIN v2.00). Hence, soil and sediment are expected to be the main targets for environmental distribution. Evaporation into air and the transport through the atmospheric compartment is not expected since the substance is not volatile based on the low vapour pressure of < 0.0001 Pa at 20 °C. Accumulation in air and the subsequent transport and deposition in other environmental compartments is not anticipated. However, if released into air, the substance is susceptible to undergo rapid indirect photodegradation by reaction with OH-radicals with a DT50 ranging from 10.11 h to 10.92 h (AOPWIN v1.92).
Furthermore, it can be concluded that the bioaccumulation potential of Benzoic acid, 4-hydroxy-, C18-22-alkyl esters is low. Due to the low water solubility (< 0.05 mg/L), this substance is expected to be extensively removed in the primary settling tank and fat trap of conventional STPs (Guidance on information requirements and chemical safety assessment, Chapter R7.b; ECHA, 2012). Furthermore, based on the high adsorption potential (log Koc > 5), a significant degree of removal of the substance from the water column in STPs is expected, due to extensive adsorption to sewage sludge (Chapter 7.a; ECHA, 2012).Therefore, discharged concentrations into water are expected to be low. If released into the aquatic compartment, adsorption to sediment and particulate matter will reduce the availability of the substance in water. Furthermore, absorbed molecules of the substance will be metabolized and the metabolites will be excreted (for details see IUCLID section 7.1). Generally, substances with log Kow > 10, such as Benzoic acid, 4-hydroxy-, C18-22-alkyl esters are expected to have BCF values < 2000 L/kg (Guidance on information requirements and chemical safety assessment, Chapter 11 (ECHA, 2012). Calculated BCF/BAF values ((BCF: 0.98 – 1.38 L/kg; BAF: 16.2 – 27.1 L/kg; Arnot-Gobas estimate, upper trophic; BCFBAF v3.01) support this assumption.
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