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Diss Factsheets
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EC number: 606-441-0 | CAS number: 201305-16-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Version / remarks:
- (1992)
- Deviations:
- yes
- Remarks:
- (study report with limited information; rechallenge was conducted sytemically)
- GLP compliance:
- no
- Type of study:
- Buehler test
- Justification for non-LLNA method:
- A valid Buehler test was available before REACh came into force, therefore no additional LLNA test was performed.
Test material
- Reference substance name:
- Benzoic acid, C12-15-alkyl esters
- EC Number:
- 270-112-4
- EC Name:
- Benzoic acid, C12-15-alkyl esters
- Cas Number:
- 68411-27-8
- IUPAC Name:
- 68411-27-8
- Details on test material:
- - Name of test material (as cited in study report): trade name
- Analytical purity: no data
- Lot/batch No.: 24,755
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- male
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 260-352 g
No further information is given in the study report.
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- water
- Concentration / amount:
- 10% (w/w) in aqueous suspension
Challengeopen allclose all
- Route:
- other: topical and systemic (not further specified)
- Vehicle:
- water
- Concentration / amount:
- 10% (w/w) in aqueous suspension
- No. of animals per dose:
- 12
- Details on study design:
- RANGE FINDING TESTS:
No information provided in the study report.
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 9
- Exposure period: 6 h
- Test groups: test substance
- Control group: no data
- Site: no data
- Frequency of applications: not specified
- Duration: Days 0-21 days
- Concentrations: 10% (w/w) aqueous suspensio)
B. CHALLENGE EXPOSURE
- No. of exposures: 2 (topical and systemic)
- Day(s) of challenge: 14 days after induction (not further specified)
- Exposure period: no data
- Test groups: test substance
- Control group: no data
- Site: no data
- Concentrations: 10% (w/w) aqueous suspensio)
- Evaluation (hr after challenge): no data
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- other: after topical challenge
- Group:
- test chemical
- Dose level:
- 10% aqueous suspension
- No. with + reactions:
- 0
- Total no. in group:
- 12
- Remarks on result:
- other: Reading: other: after topical challenge. Group: test group. Dose level: 10% aqueous suspension. No with. + reactions: 0.0. Total no. in groups: 12.0.
- Reading:
- other: after systemic challenge
- Group:
- test chemical
- Dose level:
- 10 % aqueous suspension
- No. with + reactions:
- 0
- Total no. in group:
- 12
- Remarks on result:
- other: Reading: other: after systemic challenge. Group: test group. Dose level: 10 % aqueous suspension. No with. + reactions: 0.0. Total no. in groups: 12.0.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: not classified
DSD: not classified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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