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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Published, non-standard study

Data source

Reference
Reference Type:
publication
Title:
The acute toxicity of dimethylamides in several animal species
Author:
Wiles JS & Narcisse JK
Year:
1971
Bibliographic source:
American Industrial Hygiene Association Journal, 1971

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Range-finding toxicity data in the mouse and rabbit using iv and ip administration.
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
N,N-dimethyloleamide
IUPAC Name:
N,N-dimethyloleamide
Details on test material:
No details

Test animals

Species:
other: mouse / rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: intravenous / intraperitoneal
Details on study design:
The substance was injected via the marginal ear vein (rabbit) or medial tail vein (mouse). Animals were observed for 24 hours.
Statistics:
Not reported

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD50
Effect level:
300 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Mouse / intravenous
Sex:
not specified
Dose descriptor:
LD50
Effect level:
70 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Rabbit / intravenous
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 200 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Mouse / intraperitoneal
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Rabbit / intraperitoneal
Mortality:
No details
Clinical signs:
Following intravenous administration, signs of toxicity including reduced actviity, weakness, anaesthesia, laboured breatning, cyanosis, collapse, convulsions and oronasal haemorrhage were observed in the mouse and rabbit. Similar signs were seen following intraperitoneal administration but were more dealyed and anaesthesia/analgesia was more prominent.
Body weight:
No data
Gross pathology:
No data
Other findings:
No data

Applicant's summary and conclusion

Conclusions:
Intravenous LD50 values of 300 mg/kg bw and 70 mg/kg bw are reported for the mouse and rabbit, respectively.
Intraperitoneal LD50 values of 1200 mg/kg bw and >2000 mg/kg bw are reported for the mouse and rabbit, respectively.
Executive summary:

The acute toxicity of the substance via the intravenous and intraperitoneal routes of exposure was investigated in the mouse and rabbit. Following intravenous administration, signs of toxicity including reduced actviity, weakness, anaesthesia, laboured breatning, cyanosis, collapse, convulsions and oronasal haemorrhage were observed in the mouse and rabbit. Similar signs were seen following intraperitoneal administration but were more dealyed and anaesthesia/analgesia was more prominent.I ntravenous LD50 values of 300 mg/kg bw and 70 mg/kg bw are reported for the mouse and rabbit, respectively. Intraperitoneal LD50 values of 1200 mg/kg bw and >2000 mg/kg bw are reported for the mouse and rabbit, respectively.