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Description of key information

Neodecanoic acid is not an irritant to the upper (sensory) portion of the respiratory system.

Additional information

In a study to assess respiratory irritation, mice received 30 minute head only exposures to average actual concentrations of 3607 (group 1), 1098 (group 2), or 334 (group 3) mg/m3 of neodecanoic acid. The group 1 mean respiratory rate was depressed 42.5% below the pre-exposure rates, while the group 2 rate was decreased 24.9 %. The group 3 sample respiratory rate was increased by 7.9%. One of the group 1 mice died approximately 16 minutes after the start of the exposure. The three surviving mice displayed both sensory and pulmonary responses. The RD50 based on the three exposure groups is 5491 mg/m3, although all of the groups mean decreases were less than 50%.