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Diss Factsheets
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EC number: 205-460-8 | CAS number: 141-13-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 50
- Absorption rate - inhalation (%):
- 100
Additional information
Assessment of Toxicokinetics based on the physicochemical properties of 2,6,10-trimethylundec-9-enal:
Although REACH does not specifically require generation of toxicokinetic information, it does require that all relevant available information is used to assess the toxicokinetic behaviour of a substance, and that the human health hazard assessment considers the toxicokinetic profile of the substance.
2,6,10-trimethylundec-9-enal is a small organic molecule and the physico-chemical properties suggest it is likely to be absorbed via dermal, inhalation and gastric routes following exposure. Acute and subchronic toxicity data indicate that 2,6,10-trimethylundec-9-enal is absorbed following oral administration and metabolised by the liver. No specific studies on the absorption, distribution, metabolism and elimination (ADME) of are available. However the very low toxicity of 2,6,10-trimethylundec-9-enal suggests that it may be considered inappropriate at this time to conduct further animal work to support ADME.
Endpoint Summary:
2,6,10-trimethylundec-9-enal : (Target)
Molecular weight: 210.40 g/mol
Water solubility: 0.67 mg/L at 20°C
Partition coefficient: log Kow = 6.2
The following remarks on the toxicokinetics are based on the available studies.
Experimental toxicokinetic studies were not available.
No specific studies on the absorption, distribution, metabolism and elimination (ADME) of 2,6,10-trimethylundec-9-enal are available. However the very low toxicity of 2,6,10-trimethylundec-9-enal suggests that it may be considered inappropriate at this time to conduct further animal work to support ADME.
ABSORPTION
The physicochemical characteristics of 2,6,10-trimethylundec-9-enal (log Pow 6.2) and the molecular mass are in a range suggestive of absorption from the gastro-intestinal tract subsequent to oral ingestion. This assumption of oral absorption is confirmed by the data from the subchronic oral toxicity.
N-octanol/water partition coefficient and molecular weight of 2,6,10-trimethylundec-9-enal are in ranges which favour dermal absorption.
DISTRIBUTION and METABOLISM
As a small molecule a wide distribution is expected. This assumption is confirmed by the changes shown in the repeated dose toxicity studies following oral application.
ELIMINATION
The n-Octanol/water partition coefficient (log Pow = 6.2) is suggestive of accumulation of unchanged 2,6,10-trimethylundec-9-enal in fatty tissues subsequent to absorption from gastrointestinal tract or from lungs.
The following information is taken into account for any hazard / risk assessment:
Experimental toxicokinetic studies are not available. The log Pow = 6.2 is suggestive of accumulation of unchanged 2,6-dimethylheptan-2-ol in fatty tissues subsequent to absorption from gastro-intestinal tract or from lungs.
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