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EC number: - | CAS number: 2495-39-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
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- Endpoint summary
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- Environmental data
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Sodium prop-2-enesulphonate
- EC Number:
- 219-676-5
- EC Name:
- Sodium prop-2-enesulphonate
- Cas Number:
- 2495-39-8
- Molecular formula:
- C3H6O3S.Na
- IUPAC Name:
- sodium prop-2-ene-1-sulfonate
- Details on test material:
- - Name of test substance: Golpanol ALS wasserfrei
- Test-substance No.: 09/0505-1
- Batch identification: 04749356P0
- Purity: Golpanols ALS = 71.3%; NaCI = 26.0%
- Homogeneity: The homogeneity of the test substance was provided after shaking the test-substance container.
- Storage stability: The stability under storage conditions over the study period was guaranteed by the sponsor, and the sponsor holds this responsibility.
ADDITIONAL TEST-SUBSTANCE INFORMATION
- pH-value: Ca. 5.5 (undiluted test substance, moistened with water)
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Centre Lago S. A., 01540 Vonnas, France
- Age at study initiation: 6 - 7 months
- Weight at study initiation: 4.06 kg – 4.18 kg
- Housing: Single housing
- Diet (e.g. ad libitum): Kliba-Labordiaet (Kaninchen & Meerschweinchenhaltung “GLP”), Provimi Kliba SA, Kaiseraugst, Basel, Switzerland (about 130 g/animal per day)
- Water (e.g. ad libitum):Tap water ad libitum
- Acclimation period: for at least 5 days before application
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 – 24
- Humidity (%): 30 – 70
- Photoperiod (hrs dark / hrs light): 12 h / 12 h (6.00 a.m. – 6.00 p.m. / 6.00 p.m. – 6.00 a.m.)
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated left eye
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL bulk volume (about 34 mg of the comminuted test substance) - Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 28 days
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): the treated eye of the animal(s) was rinsed with 3 to 6 mL of hand warm tap water for 1 to 2 minutes using a syringe with a blunt probe.
SCORING SYSTEM: Draize Scoring System
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: No effects observed.
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: No effects observed.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 1.7
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 1.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 1.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: No effects were observed.
- Other effects:
- Discharge (see table 1)
Any other information on results incl. tables
Table 1: irritant response, data for each individual animal at each observation time as well as calculation of the means.
Exposition: | 24 h | |||||||
Animal | Reading | Opacity | Cornea area | Iritis | Redness | Chemosis | Discharge | Symptoms |
1 | 1 h | 0 | 0 | 0 | 2 | 3 | 3 | scleral vessels injected, circular |
2 | 1 h | 0 | 0 | 0 | 2 | 2 | 3 | scleral vessels injected, circular |
3 | 1 h | 0 | 0 | 0 | 2 | 2 | 2 | scleral vessels injected, circumscribed area |
1 | 24 h | 0 | 0 | 0 | 2 | 2 | 1 | scleral vessels injected, circular |
2 | 24 h | 0 | 0 | 0 | 2 | 1 | 1 | scleral vessels injected, circumscribed area |
3 | 24 h | 0 | 0 | 0 | 2 | 0 | 1 | scleral vessels injected, circumscribed area |
1 | 48 h | 0 | 0 | 0 | 2 | 1 | 0 | scleral vessels injected, circumscribed area |
2 | 48 h | 0 | 0 | 0 | 1 | 0 | 1 | scleral vessels injected, circumscribed area |
3 | 48 h | 0 | 0 | 0 | 1 | 0 | 1 | scleral vessels injected, circumscribed area |
1 | 72 h | 0 | 0 | 0 | 1 | 0 | 0 | scleral vessels injected, circumscribed area |
2 | 72 h | 0 | 0 | 0 | 1 | 0 | 0 | scleral vessels injected, circumscribed area |
3 | 72 h | 0 | 0 | 0 | 1 | 0 | 0 | scleral vessels injected, circumscribed area |
1 | 7 d | 0 | 0 | 0 | 0 | 0 | 0 | |
2 | 7 d | 0 | 0 | 0 | 0 | 0 | 0 | |
3 | 7 d | 0 | 0 | 0 | 0 | 0 | 0 | |
1 | 24 - 72 h | 0,00 | 0,00 | 1,67 | 1,00 | |||
2 | 24 - 72 h | 0,00 | 0,00 | 1,33 | 0,33 | |||
3 | 24 - 72 h | 0,00 | 0,00 | 1,33 | 0,00 | |||
mean | 24 - 72 h | 0,00 | 0,00 | 1,44 | 0,44 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: CLP (1272/2008/EC)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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