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Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer-reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Fragrance Material Monograph for Allyl butyrate
Author:
Edited by D. L. J. Opdyke
Year:
1977
Bibliographic source:
Food and Cosmetics Toxicology, Volume 15, Issue 6, December 1977, Pages 613-614

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as below
Principles of method if other than guideline:
Acute dermal toxicity study of Allyl butyrate in rabbits
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Allyl butyrate
EC Number:
218-129-8
EC Name:
Allyl butyrate
Cas Number:
2051-78-7
Molecular formula:
C7H12O2
IUPAC Name:
prop-2-en-1-yl butanoate
Test material form:
liquid
Details on test material:
- Name of test material (IUPAC name): 2-Propen-1-yl butanoate
- Common name: Allyl butyrate
- Molecular formula: C7H12O2
- Molecular weight: 128.17 g/mol
- Smiles notation: C(OCC=C)(CCC)=O
- InChl: 1S/C7H12O2/c1-3-5-7(8)9-6-4-2/h4H,2-3,5-6H2,1H3
- Substance type: Organic
- Physical state: Liquid
Specific details on test material used for the study:
- Name of test material (IUPAC name): 2-Propen-1-yl butanoate
- Common name: Allyl butyrate
- Molecular formula: C7H12O2
- Molecular weight: 128.17 g/mol
- Smiles notation: C(OCC=C)(CCC)=O
- InChl: 1S/C7H12O2/c1-3-5-7(8)9-6-4-2/h4H,2-3,5-6H2,1H3
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Type of coverage:
other: Dermal
Vehicle:
not specified
Details on dermal exposure:
not specified
Duration of exposure:
not specified
Doses:
530 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
530 mg/kg bw
Based on:
test mat.
95% CL:
350 - 840
Remarks on result:
other: 50 % mortality observed
Mortality:
50 % mortality was observed in treated rat at 530 mg/kg bw
Clinical signs:
other: not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
LD50 was considered to be 530 mg/kg bw (350-840) when rabbits was treated with Allyl butyrate dermally.
Executive summary:

In a acute dermal toxicity study, rabbits were treated with Allyl butyrate in the concentration of 530 mg/kg bw.50 % mortality was observed in treated rabbits at 530 mg/kg bw. Therefore,LD50 was considered to be 530 mg/kg bw (350 -840) when rabbits was treated with Allyl butyrate dermally