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EC number: 931-227-1 | CAS number: 28497-59-8
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE
OECD Toolbox Version 3.4
2. SMILES
O=C(C(=C)C)OCC(COC(=O)C(=C)C)O - Principles of method if other than guideline:
- - Justification of QSAR prediction: see field 'Justification for type of information',
- GLP compliance:
- no
- Specific details on test material used for the study:
- O=C(C(=C)C)OCC(COC(=O)C(=C)C)O
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 80 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Conclusions:
- EC50 (48h) Daphnia magna: 80 mg/l
- Executive summary:
EC50 Daphnia magna (48h) of Glycerol 1,3 dimethacrylate (199 mg/L) is predicted from category members using trend analysis based on 8 values within the range 4.56 - 380 mg/L from 8 category members. Category members are single substances or mixtures and are selected based on the profile of the target chemical. Only substances with vaild experimental data are listed in the category.
The target chemical FALLS within applicability domain of the prediction.
The predicted value of 199 mg/l is based on Log Kow 1,16 which is calculated by KowWin.
Glycerol 1,3 dimethacrylate is an ether methacrylate and log Kow of ethers are known to be difficult to calculate. The measured log Kow is 2.05. The QSAR prediction was used to create the graphic which shows the correlation of the acute toxicity to daphnia magna of the different methacrylates and log Kow. (see also 4.7 Partition coefficient).
The correlation of EC50 is consistent with increasing log Kow and therefore the diagram was used to read the EC50 Daphnia magna of Glycerol 1,3 dimethacrylate with log Kow 2,05.
An EC50, log (1/mol/l) of 3.05 was read from the y-axis of the graphic which recalculated corresponds to an EC50 Daphnia magna (48h) of 80 mg/l.
Reference
The predicted value of 199 mg/l is based on Log Kow 1,16 which is calculated by KowWin.
Glycerol 1,3 dimethacrylate is an ether methacrylate and log Kow of ethers are known to be difficult to calculate. The measured log Kow is 2.05. The QSAR prediction was used to create the graphic which shows the correlation of the acute toxicity to daphnia magna of the different methacrylates and log Kow. (see also 4.7 Partition coefficient).
The correlation of EC50 is consistent with increasing log Kow and therefore the diagram was used to read the EC50 Daphnia magna of Glycerol 1,3 dimethacrylate with log Kow 2,05.
EC50, log (1/mol/l) of 3.05 was read from the y-axis of the graphic which recalculated corresponds to an EC50 Daphnia magna (48h) of 80 mg/l.
Description of key information
EC50 Daphnia magna (48h) of Glycerol 1,3 dimethacrylate (199 mg/L) is predicted from category members using trend analysis based on 8 values within the range 4.56 - 380 mg/L from 8 category members. Category members are single substances or mixtures and are selected based on the profile of the target chemical. Only substances with vaild experimental data are listed in the category.
The target chemical FALLS within applicability domain of the prediction.
The predicted value of 199 mg/l is based on Log Kow 1,16 which is calculated by KowWin.
Glycerol 1,3 dimethacrylate is an ether methacrylate and log Kow of ethers are known to be difficult to calculate. The measured log Kow is 2.05. The QSAR prediction was used to create the graphic which shows the correlation of the acute toxicity to daphnia magna of the different methacrylates and log Kow. (see also 4.7 Partition coefficient).
The correlation of EC50 is consistent with increasing log Kow and therefore the diagram was used to read the EC50 Daphnia magna of Glycerol 1,3 dimethacrylate with log Kow 2,05.
An EC50, log (1/mol/l) of 3.05 was read from the y-axis of the graphic which recalculated corresponds to an EC50 Daphnia magna (48h) of 80 mg/l.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 80 mg/L
Additional information
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