Registration Dossier
Registration Dossier
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EC number: 225-202-8 | CAS number: 4712-55-4
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- no data available: testing technically not feasible
Marine water
- Hazard assessment conclusion:
- no data available: testing technically not feasible
STP
- Hazard assessment conclusion:
- no data available: testing technically not feasible
Sediment (freshwater)
- Hazard assessment conclusion:
- no data available: testing technically not feasible
Sediment (marine water)
- Hazard assessment conclusion:
- no data available: testing technically not feasible
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- no data available: testing technically not feasible
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
DPP hydrolyzes rapidly (0.5 -1 hr) half-life and therefore the CSA will evaluate its primary hydrolysis product - phenol.
Phenol PNECs
Upon hydrolysis, one mole of DPP produces two moles of phenol. As such, it is the primary hydrolysis product for DPP. Phenol is well studied and reviewed. There are established PNECs in the published risk assessment report (ECB 2006 Phenol Risk Assessment).
PNECaqua= 7.7 μg/l (ECB 2006 Phenol Risk Assessment)
PNECmicroorganism= 2.1 mg/l (ECB 2006 Phenol Risk Assessment)
PNECsoil= 136 μg/kg dry weight (ECB 2006 Phenol Risk Assessment)
PNECsediment =115.6 mg/kg dw (ECB 2006 Phenol Risk Assessment)
Phosphorous Acid
Phosphorous acid is also a hydrolysis product of DPP; one mole of DPP produces one mole of phosphorous acid. Since the element phosphorous is an essential plant nutrient and phosphorous acid and its salts have low relatively low plant, animal and human toxicity, it appears that phosphorous acid will not have a significant impact on the environmental assessment of DPP. As such, the environmental assessment has focused just on phenol.
Conclusion on classification
Phenol is classified as Aquatic Chronric 2 (H411) and thus this classification has been applied to DPP. This phenol classification is expected to be the most relevant aquatic classification for DPP. An additional classification of Aquatic Acute 1 (H400) was added based on preliminary ECOSAR acute results that were later determined to be based on modelling of the incorrect structure. The SMILES code used for the preliminary modelling was OP(Oc1ccccc1)(Oc2ccccc2), when it should have been O=P(Oc1ccccc1)(Oc2ccccc2). The modelled data on the proper structure does not indicate a need for the Aquatic Acute 1 classification.
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