Registration Dossier
Registration Dossier
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EC number: 225-202-8 | CAS number: 4712-55-4
Endpoint summary
Administrative data
Description of key information
Diphenyl phosphonate (DPP) is expected to have similar toxicology to that of triphenyl phosphite (TPP), which is a structurally similar compound and minor constituent in DPP. This relationship is explained more fully in the paper attached in Section 13 of this dossier. An LLNA study was conducted in 2010 (Sanders 2010) on TPP. This study showed that TPP is a strong skin sensitiser. This same conclusion has been applied to DPP.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
TPP showed positive reactions at test concentrations of 2.5%, 5%, and 10% in a new local lymph node assay (LLNA) (Harlan 2010). The EC3 value from the study was determined to be 1.4%.
Migrated from Short description of key information:
EC3 = 1.4%; TPP is a skin sensitiser.
Justification for classification or non-classification
TPP has been classified as Skin Sens. 1.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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